RIMS1 and SNAP25

Data Source:
HPRD (in vitro)

		RIMS1	SNAP25
Description		regulating synaptic membrane exocytosis 1	synaptosome associated protein 25
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Presynaptic Membrane Cell Projection Presynaptic Active Zone Cytoskeleton Of Presynaptic Active Zone	Photoreceptor Inner Segment Cytoplasm Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Synaptic Vesicle Voltage-gated Potassium Channel Complex Membrane Growth Cone BLOC-1 Complex SNARE Complex Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Vesicle Specific Granule Membrane Somatodendritic Compartment Presynaptic Membrane Neuron Projection Perinuclear Region Of Cytoplasm Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Tertiary Granule Membrane Postsynapse Glutamatergic Synapse
	Molecular Function	RNA Binding Protein Binding GTPase Regulator Activity Small GTPase Binding Ion Channel Binding Metal Ion Binding	Voltage-gated Potassium Channel Activity SNAP Receptor Activity Protein Binding Syntaxin-1 Binding Syntaxin Binding Calcium-dependent Protein Binding
	Biological Process	Intracellular Protein Transport Neurotransmitter Secretion Visual Perception Positive Regulation Of Gene Expression Glutamate Secretion Synaptic Vesicle Exocytosis Calcium-ion Regulated Exocytosis Cell Differentiation Regulation Of Membrane Potential Regulated Exocytosis Secretion Regulation Of Neurotransmitter Secretion Regulation Of Synaptic Plasticity Calcium Ion-regulated Exocytosis Of Neurotransmitter Regulation Of Catalytic Activity Positive Regulation Of Synaptic Transmission Response To Stimulus Acrosomal Vesicle Exocytosis Membrane Fusion Protein-containing Complex Assembly Positive Regulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Dendrite Extension Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential	Neurotransmitter Uptake Exocytosis Vesicle Fusion Chemical Synaptic Transmission Neurotransmitter Secretion Locomotory Behavior Associative Learning Regulation Of Neuron Projection Development Glutamate Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Neutrophil Degranulation Regulation Of Insulin Secretion Long-term Synaptic Potentiation Potassium Ion Transmembrane Transport Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Neurotransmitter Receptor Internalization
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Other interleukin signaling Toxicity of botulinum toxin type A (botA) Toxicity of botulinum toxin type C (botC) Toxicity of botulinum toxin type E (botE) Neutrophil degranulation GABA synthesis, release, reuptake and degradation
Drugs			Botulinum toxin type A
Diseases		Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485) Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Chronotype ( 30696823) Cognitive performance ( 20125193) Lung cancer ( 28604730) Lung cancer in never smokers ( 28604730) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Refractive error ( 32231278) Response to mTOR inhibitor (rapamycin) ( 24009623) Rosacea symptom severity ( 29771307) Schizophrenia ( 25056061 29483656 30285260) Squamous cell lung carcinoma ( 28604730) Triglyceride levels ( 32203549)	Brain imaging measurements (variance) ( 32047264) Cardiac hypertrophy ( 21348951) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603)
Interacting Genes		15 interacting genes: CACNA1B CACNA1C CAMK2A ERC1 ERC2 RAB10 RAB26 RAB27A RAB37 RAB3A SNAP25 STX1A SYT1 UNC13B YWHAH	39 interacting genes: APP CENPF CPLX1 DNM1 FBXO7 GOSR1 HGS ITSN1 KCNB1 KIF5B NAPA PRKACA PRKCA PRRT2 RIMS1 SCAMP1 SNAPIN SRCIN1 STX11 STX12 STX19 STX1A STX2 STX3 STX4 STX5 STXBP6 SYT1 SYT3 SYT9 TRIM9 UQCC2 VAMP2 VAMP7 VAMP8 WASHC3 ZDHHC17 ZNF177 ZNF559-ZNF177
Entrez ID		22999	6616
HPRD ID		09435	02637
Ensembl ID		ENSG00000079841	ENSG00000132639
Uniprot IDs		B7Z7W2 B7Z9Z3 Q3ZCW0 Q86UR5	P60880
PDB IDs		2CSS	1KIL 1XTG 2N1T 3DDA 3DDB 3RK2 3RK3 3RL0 3ZUR 5W7I 5W7J 6JLH
Enriched GO Terms of Interacting Partners?
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