SORCS3 and AZIN1

Data Source:
BioGRID (affinity chromatography technology)

		SORCS3	AZIN1
Description		sortilin related VPS10 domain containing receptor 3	antizyme inhibitor 1
Image		No pdb structure
GO Annotations	Cellular Component	Membrane Integral Component Of Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Neuropeptide Receptor Activity	Ornithine Decarboxylase Activity Protein Binding Ornithine Decarboxylase Activator Activity
	Biological Process	Neuropeptide Signaling Pathway Learning Memory Regulation Of Long-term Synaptic Depression	Regulation Of Cellular Amino Acid Metabolic Process Putrescine Biosynthetic Process From Ornithine Negative Regulation Of Protein Catabolic Process Regulation Of Catalytic Activity Positive Regulation Of Polyamine Transmembrane Transport
Pathways			Regulation of ornithine decarboxylase (ODC)
Drugs
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Attention deficit hyperactivity disorder ( 30478444) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Depression ( 29700475) Diabetic kidney disease ( 26305897) Diastolic blood pressure ( 30224653) Feeling miserable ( 29500382) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Intelligence (MTAG) ( 29326435) Major depressive disorder ( 27479909) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Mood instability ( 31168069) Multisite chronic pain ( 31194737) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Rosacea symptom severity ( 29771307) Subclinical trait of interstitial lung disease (basilar percentage of high attenuation areas on CT scan) ( 28521775) Systolic blood pressure ( 30578418)	Airway imaging phenotypes ( 26030696) Apolipoprotein A1 levels ( 32203549) Granulocyte count ( 27863252) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Neutrophil count ( 27863252) PR interval ( 32439900) QT interval ( 24952745) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) TPE interval (resting) ( 32386560) Waist circumference adjusted for body mass index ( 28552196) White blood cell count ( 32888494)
Interacting Genes		2 interacting genes: ATXN1 NGF	8 interacting genes: ABCC2 ADSS1 ARNTL CDKN2A FANCA FANCC KHDRBS1 OAZ3
Entrez ID		22986	51582
HPRD ID		12100	07443
Ensembl ID		ENSG00000156395	ENSG00000155096
Uniprot IDs		Q86XB2 Q9UPU3	A0A024R9C7 B3KTF6 O14977
PDB IDs			4ZGZ
Enriched GO Terms of Interacting Partners?
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