PAXIP1 and SCAMP5

Data Source:
BioGRID (two hybrid)

		PAXIP1	SCAMP5
Description		PAX interacting protein 1	secretory carrier membrane protein 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nuclear Matrix Histone Methyltransferase Complex MLL3/4 Complex	Golgi Membrane Plasma Membrane Integral Component Of Membrane Synaptic Vesicle Membrane Trans-Golgi Network Membrane Recycling Endosome Membrane
	Molecular Function	Protein Binding	Protein Binding Protein-containing Complex Binding
	Biological Process	Positive Regulation Of Histone H3-K36 Methylation Vasculogenesis Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Response To Ionizing Radiation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Positive Regulation Of Histone Acetylation Negative Regulation Of DNA-binding Transcription Factor Activity Endothelial Cell Migration Positive Regulation Of Isotype Switching Positive Regulation Of Isotype Switching To IgG Isotypes Histone H3-K4 Methylation Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Adipose Tissue Development Chorion Development Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Response To DNA Damage Stimulus	Positive Regulation Of Cytokine Production Exocytosis Protein Transport Response To Endoplasmic Reticulum Stress Negative Regulation Of Endocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis Nonhomologous End-Joining (NHEJ)
Drugs
Diseases
GWAS		Bladder cancer (smoking interaction) ( 24662972) Metabolite levels ( 23823483)	Blood trace element (Zn levels) ( 23720494) Caffeine consumption ( 21490707) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) LDL cholesterol ( 30275531) Mean corpuscular volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Systemic lupus erythematosus ( 26502338) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		91 interacting genes: A2M APP ATP1B1 ATP1B3 BTBD16 BTBD6 C2orf42 CABYR CATSPERG CBX8 CCNDBP1 CIAO2B CLU COMTD1 CYB5R4 DCP1A DIS3L DNAJA1 DNAJB11 DYNC2H1 ECSIT EIF3I EIF5B EP300 EPB41L3 FAHD1 FBLN5 FUCA1 H2AX H3C1 HNRNPLL HSPA14 HSPA4L INTS7 LACTB MAPRE2 MAST1 MRPL33 MT-ND1 MT2A MTIF3 MTNR1A NOS3 NPC2 NUPR1 NXT1 PAGR1 PAX2 PCBP2 PCYT1B PGGHG PGM1 PIAS1 PIAS2 PKP4 PLCD1 PML POM121 PPHLN1 PPIA PPP2R5C PRDX6 PSMA6 RNF32 RPA1 RPL12 RPS20 RPS27A SCAMP5 SCCPDH SELENOV SH3GL2 SMAD2 SNX3 SOX30 SPAG4 SPATA18 SUGT1 SUZ12 TCN2 TECR TM2D3 TMEM120A TP53BP1 TRAPPC8 UMPS WDR48 XAGE1B ZBTB8A ZNF251 ZNF280B	23 interacting genes: AQP6 ARFIP2 CERS4 CREB3 DNAJC5 FATE1 GDNF HSD17B13 MUC1 PAXIP1 PIGP PITPNC1 PLAU SGPL1 SH3GL1 SHISAL1 SLC10A6 SLC9A7 TIMMDC1 TLCD4 TMEM14B TMX2 TTPA
Entrez ID		22976	192683
HPRD ID		08491	18020
Ensembl ID		ENSG00000157212	ENSG00000198794
Uniprot IDs		Q6ZW49	A0A0A8K8F5 Q8TAC9
PDB IDs		3SQD
Enriched GO Terms of Interacting Partners?
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