P2RX2 and P2RX3

Data Source:
HPRD (in vitro)

		P2RX2	P2RX3
Description		purinergic receptor P2X 2	purinergic receptor P2X 3
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Nuclear Inner Membrane Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane Neuronal Cell Body Receptor Complex Postsynapse	Integral Component Of Nuclear Inner Membrane Rough Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Neuronal Cell Body Terminal Bouton Dendritic Spine Receptor Complex Membrane Raft Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Integral Component Of Presynaptic Membrane
	Molecular Function	Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Cation Channel Activity ATP Binding Ligand-gated Ion Channel Activity Identical Protein Binding	Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Cation Channel Activity ATP Binding Identical Protein Binding
	Biological Process	Response To Hypoxia Response To Ischemia Detection Of Hypoxic Conditions In Blood By Carotid Body Chemoreceptor Signaling Neuromuscular Synaptic Transmission Neuromuscular Junction Development Blood Coagulation Sensory Perception Of Sound Response To Carbohydrate Positive Regulation Of Calcium Ion Transport Into Cytosol Urinary Bladder Smooth Muscle Contraction Peristalsis Response To ATP Purinergic Nucleotide Receptor Signaling Pathway Behavioral Response To Pain Skeletal Muscle Fiber Development Positive Regulation Of Calcium-mediated Signaling Sensory Perception Of Taste Excitatory Postsynaptic Potential Cation Transmembrane Transport	Response To Hypoxia Signal Transduction Neuromuscular Synaptic Transmission Blood Coagulation Response To Heat Response To Cold Response To Mechanical Stimulus Response To Carbohydrate Positive Regulation Of Calcium Ion Transport Into Cytosol Urinary Bladder Smooth Muscle Contraction Neuronal Action Potential Peristalsis Purinergic Nucleotide Receptor Signaling Pathway Regulation Of Synaptic Plasticity Positive Regulation Of Calcium-mediated Signaling Sensory Perception Of Taste Excitatory Postsynaptic Potential Behavioral Response To Formalin Induced Pain Protein Homotrimerization Cellular Response To ATP Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Positive Regulation Of Sensory Perception Of Pain
Pathways		Elevation of cytosolic Ca2+ levels Platelet homeostasis	Elevation of cytosolic Ca2+ levels Platelet homeostasis
Drugs		Promethazine	Promethazine
Diseases
GWAS		Body mass index ( 26426971)	Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Eosinophil percentage of white cells ( 27863252) Low high density lipoprotein cholesterol levels ( 26879886) Triglyceride levels ( 32203549)
Interacting Genes		3 interacting genes: GABRR1 P2RX1 P2RX3	1 interacting genes: P2RX2
Entrez ID		22953	5024
HPRD ID		15984	09016
Ensembl ID		ENSG00000187848	ENSG00000109991
Uniprot IDs		Q32MC3 Q9UBL9	P56373
PDB IDs			5SVJ 5SVK 5SVL 5SVM 5SVP 5SVQ 5SVR 5SVS 5SVT 5YVE 6AH4 6AH5
Enriched GO Terms of Interacting Partners?
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