SEC31A and TSC22D2

Data Source:
BioGRID (two hybrid)

		SEC31A	TSC22D2
Description		SEC31 homolog A, COPII coat complex component	TSC22 domain family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Vesicle Coat COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site
	Molecular Function	Structural Molecule Activity Protein Binding Calcium-dependent Protein Binding
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II IRE1-mediated Unfolded Protein Response COPII Vesicle Coating Response To Calcium Ion COPII-coated Vesicle Cargo Loading	Regulation Of Transcription By RNA Polymerase II Response To Osmotic Stress
Pathways		COPII-mediated vesicle transport MHC class II antigen presentation XBP1(S) activates chaperone genes Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases
GWAS		Adult asthma ( 27611488) Neutrophil percentage of white cells ( 27863252)	Adiponectin levels ( 22479202) Apolipoprotein A1 levels ( 32203549) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cortical surface area (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 29891935) HDL cholesterol levels ( 32203549) Intraocular pressure ( 29235454) Macular thickness ( 30535121) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444) Moyamoya disease ( 29273593) PR interval ( 32439900) Pulse pressure ( 27841878) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) Triglyceride levels ( 32203549 32154731) Type 2 diabetes ( 30054458 30297969) Waist circumference ( 26785701)
Interacting Genes		14 interacting genes: APC ARIH1 FHL5 KLHL12 MYOM2 PDCD6 PEF1 PFDN1 PRNP REL SEC13 TNNT1 TSC22D2 USP8	42 interacting genes: ANAPC10 ANKRD36 ARID2 ATP1B1 CCDC141 CCDC144A CLIP1 DNAAF11 ENOPH1 EPCAM F8 FLNB GPBP1 ITGA2 KIAA0586 LOXHD1 LPL MED13 MPDZ MSH3 MTIF2 NGRN OSBPL1A PRMT3 PSMA7 PSMA8 RBL1 REV1 RNF2 SAP18 SCEL SEC31A SNX3 SPEF2 STK39 TMA7 TTN UFM1 WNK3 ZMYM2 ZNF143 ZNF251
Entrez ID		22872	9819
HPRD ID		15314	11101
Ensembl ID		ENSG00000138674	ENSG00000196428
Uniprot IDs		A0A024RDH6 A1LU61 O94979	B4DN36 O75157
PDB IDs		3WXA
Enriched GO Terms of Interacting Partners?
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