AAK1 and CEP68

Data Source:
HPRD (in vivo)

		AAK1	CEP68
Description		AP2 associated kinase 1	centrosomal protein 68
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Clathrin-coated Pit Extrinsic Component Of Plasma Membrane Clathrin-coated Vesicle Cell Leading Edge Terminal Bouton	Nucleoplasm Centrosome Cytosol Cell Junction Centriolar Satellite
	Molecular Function	Protein Serine/threonine Kinase Activity Notch Binding Protein Binding ATP Binding AP-2 Adaptor Complex Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding Protein Kinase Binding Protein Domain Specific Binding
	Biological Process	Protein Phosphorylation Endocytosis Regulation Of Protein Localization Positive Regulation Of Notch Signaling Pathway Protein Autophosphorylation Protein Stabilization Membrane Organization Regulation Of Clathrin-dependent Endocytosis	Centrosome Cycle Centriole-centriole Cohesion Protein Localization To Organelle
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		Fostamatinib
Diseases
GWAS		Dentures ( 31235808) Hematocrit ( 32888494) Hemoglobin ( 32888494) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Parkinson's disease (age of onset) ( 19772629) Serum thyroid-stimulating hormone levels ( 25436638) Urate levels ( 31578528)	Apolipoprotein A1 levels ( 32203549) Atrial fibrillation ( 28416818 28416822 30061737 29892015) HDL cholesterol levels ( 32203549) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Metabolic syndrome ( 31589552) Platelet distribution width ( 32888494) Pulse pressure ( 28135244 27841878 30578418) Systolic blood pressure ( 27841878 30578418) Triglyceride levels ( 32203549) Triglycerides ( 30275531 25961943) Type 2 diabetes ( 30054458 30297969 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		1 interacting genes: APP	9 interacting genes: COG2 CTBP1 CTBP2 HGS MCM7 TRAF3IP3 TRIM54 TSNAX USHBP1
Entrez ID		22848	23177
HPRD ID		10620	13808
Ensembl ID		ENSG00000115977	ENSG00000011523
Uniprot IDs		Q2M2I8	Q76N32
PDB IDs		4WSQ 5L4Q 5TE0
Enriched GO Terms of Interacting Partners?
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