RAB11FIP2 and CXCR2

Data Source:
HPRD (in vivo)

		RAB11FIP2	CXCR2
Description		RAB11 family interacting protein 2	C-X-C motif chemokine receptor 2
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GO Annotations	Cellular Component	Phagocytic Cup Nucleoplasm Endosome Cytoplasmic Vesicle Membrane Cell Projection Intracellular Membrane-bounded Organelle Recycling Endosome Membrane	Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Microtubule Cytoskeleton Membrane Secretory Granule Membrane Mast Cell Granule Mitotic Spindle
	Molecular Function	Protein Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity	Interleukin-8 Receptor Activity G Protein-coupled Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding Interleukin-8 Binding
	Biological Process	Renal Water Homeostasis Phagocytosis Establishment Of Cell Polarity TRAM-dependent Toll-like Receptor 4 Signaling Pathway Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of GTPase Activity Regulated Exocytosis Positive Regulation Of Protein Localization To Plasma Membrane	Dendritic Cell Chemotaxis Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Population Proliferation Calcium-mediated Signaling Neutrophil Chemotaxis Receptor Internalization Interleukin-8-mediated Signaling Pathway Neutrophil Activation Neutrophil Degranulation Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Vasopressin regulates renal water homeostasis via Aquaporins	Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation
Drugs
Diseases
GWAS		Age spots ( 29895819) Asthma (sex interaction) ( 24824216) Celiac disease ( 23936387) Freckles ( 29895819) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Serum uric acid levels ( 30993211 29403010)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Smooth-surface caries ( 23470693) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)
Interacting Genes		20 interacting genes: AP2A1 CXCR2 EHD1 FAM90A1 FBXO17 FKBP6 HSF2BP ITSN1 KANK2 LRRK2 MARK2 MYO5B PIBF1 RAB11A RAB11B RAB11FIP4 RAB25 REPS1 YWHAE YWHAG	32 interacting genes: ADRA1A ARRB1 ATP13A1 C4orf3 CLDN22 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR1 EMP1 FKBP8 GNA14 GNA15 GNAI2 GNAI3 GPRASP1 GRIA1 MYO5B PPBP PPP2CA RAB11FIP2 RGS12 SLC18A2 SLC39A2 SMCO4 ST13 TMEM147 TMEM80 TRARG1
Entrez ID		22841	3579
HPRD ID		10548	00907
Ensembl ID		ENSG00000107560	ENSG00000180871
Uniprot IDs		Q7L804	P25025 Q53PC4
PDB IDs		2GZD 2GZH 2K6S 3TSO 4C4P 6S8X	4Q3H 5TYT 6KVA 6KVF 6LFM 6LFO
Enriched GO Terms of Interacting Partners?
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