FGF12 and MAPK13

Data Source:
BioGRID (enzymatic study)

		FGF12	MAPK13
Description		fibroblast growth factor 12	mitogen-activated protein kinase 13
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Synapse	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Growth Factor Activity Sodium Channel Regulator Activity Ion Channel Binding	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding
	Biological Process	Regulation Of Membrane Depolarization Signal Transduction Cell-cell Signaling Chemical Synaptic Transmission Nervous System Development Heart Development Adult Locomotory Behavior Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Sodium Ion Transport Neuromuscular Process Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Neuronal Action Potential Regulation Of Sodium Ion Transmembrane Transport Regulation Of Voltage-gated Sodium Channel Activity Regulation Of Sodium Ion Transmembrane Transporter Activity Negative Regulation Of Cation Channel Activity	Response To Osmotic Stress Cell Cycle Peptidyl-serine Phosphorylation Positive Regulation Of Interleukin-6 Production Cellular Response To UV Intracellular Signal Transduction Positive Regulation Of Inflammatory Response Stress-activated MAPK Cascade Cellular Response To Hydrogen Peroxide Cellular Response To Interleukin-1 Cellular Response To Sorbitol Cellular Response To Anisomycin Cellular Response To Sodium Arsenite
Pathways		Phase 0 - rapid depolarisation	NOD1/2 Signaling Pathway p38MAPK events DSCAM interactions VEGFA-VEGFR2 Pathway
Drugs			Minocycline KC706 Fostamatinib
Diseases
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Bipolar disorder ( 31043756) Gut microbiota relative abundance (Ruminococcus belonging to family Erysipelotrichaceae) ( 33208821) Hip circumference adjusted for BMI ( 28552196) Idiopathic dilated cardiomyopathy ( 29495422) Ileal carcinoids ( 21139019) Major depressive disorder ( 23377640) Metabolite levels ( 19043545) Post bronchodilator FEV1/FVC ratio ( 26634245) PR interval ( 32439900) Serum metabolite concentrations in chronic kidney disease ( 29545352) Severe influenza A (H1N1) infection ( 26379185) Sleep quality ( 23728906)	Birth weight ( 31043758) Blood protein levels ( 30072576 29875488) Offspring birth weight ( 31043758)
Interacting Genes		25 interacting genes: APP COIL CT45A1 DACH1 DCTD DPPA2 GRIP1 IKZF1 LZTS2 MAPK13 MAPK8IP2 NEDD4 NEDD4L PJA1 RBAK RNF151 RP9 SMURF1 SRPK1 SRPK2 STAC3 THAP1 YWHAE ZNF460 ZNF79	16 interacting genes: AKIP1 ANKLE2 APP ATF2 EEF2K FGF12 GPX4 HTRA2 MAP2K6 MAP3K4 MAPKAPK3 MAPKAPK5 MAPT MBP SMAD4 SQSTM1
Entrez ID		2257	5603
HPRD ID		03303	09113
Ensembl ID		ENSG00000114279	ENSG00000156711
Uniprot IDs		P61328	A0A024RD04 O15264
PDB IDs		1Q1U 4JQ0	3COI 4EYJ 4EYM 4MYG 4YNO 5EKN 5EKO
Enriched GO Terms of Interacting Partners?
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