CDHR3 and NEIL2

Data Source:
BioGRID (two hybrid)

		CDHR3	NEIL2
Description		cadherin related family member 3	nei like DNA glycosylase 2
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GO Annotations	Cellular Component	Plasma Membrane Adherens Junction Integral Component Of Membrane Catenin Complex	Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle Mitotic Spindle
	Molecular Function	Virus Receptor Activity Calcium Ion Binding Protein Binding Cadherin Binding	Damaged DNA Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein Binding Microtubule Binding Zinc Ion Binding DNA N-glycosylase Activity Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
	Biological Process	Cell Morphogenesis Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Multicellular Organism Development Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Adherens Junction Organization Viral Entry Into Host Cell Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules	Base-excision Repair Depyrimidination
Pathways			Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Drugs			Iron Copper Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases
GWAS		Asthma ( 27182965) Asthma (childhood onset) ( 24241537) Childhood ear infection ( 27182965 28928442) Multiple sclerosis ( 31604244) PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575) Smoking cessation in chronic obstructive pulmonary disease ( 29631575)	Alcohol dependence ( 23942779) Apolipoprotein A1 levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Frontotemporal dementia ( 29724592) Frontotemporal dementia with GRN mutation ( 29724592) Medication use (calcium channel blockers) ( 31015401) Neutrophil count ( 21507922) Nicotine use ( 23942779) Polycystic ovary syndrome ( 26284813) Processed meat consumption ( 32066663) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		3 interacting genes: CXorf38 NEIL2 PARVG	10 interacting genes: CDHR3 CRX EP300 HOMEZ INCA1 LCN2 MEOX1 PAX5 REL TRIM27
Entrez ID		222256	252969
HPRD ID		08042	16406
Ensembl ID		ENSG00000128536	ENSG00000154328
Uniprot IDs		B7Z8X2 E7EQG5 Q6ZTQ4	A0A024R361 Q969S2
PDB IDs		6PPO 6PSF	1VZP
Enriched GO Terms of Interacting Partners?
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