ZBTB12 and RAP1GAP

Data Source:
HPRD (in vitro, two hybrid)

		ZBTB12	RAP1GAP
Description		zinc finger and BTB domain containing 12	RAP1 GTPase activating protein
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm	Golgi Membrane Cytoplasm Cytosol Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	GTPase Activity GTPase Activator Activity Protein Binding Small GTPase Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II	Signal Transduction Axon Guidance Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity Negative Regulation Of Microvillus Assembly
Pathways			Rap1 signalling RET signaling
Drugs
Diseases
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Hematology traits ( 23263863) Inflammatory bowel disease ( 28067908) Rosacea symptom severity ( 29771307) Ulcerative colitis ( 28067908)	Abdominal aortic calcification levels ( 31659325) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Liver enzyme levels ( 18940312) Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483) Neurocognitive impairment in HIV-1 infection (continuous) ( 28447399) Serum alkaline phosphatase levels ( 31666285)
Interacting Genes		5 interacting genes: GRB2 HRAS NCK2 RAP1GAP ZBTB26	15 interacting genes: AFDN BRAF CDK1 CSNK1G2 DYNC1I1 GNAZ MAP1LC3B MAPK6 MEX3B PFN2 PLK1 PRKACA RALGDS RAP1A ZBTB12
Entrez ID		221527	5909
HPRD ID		15691	02609
Ensembl ID		ENSG00000204366	ENSG00000076864
Uniprot IDs		Q9Y330	A0A024RAB5 P47736 X6R8W7
PDB IDs			1SRQ 3BRW
Enriched GO Terms of Interacting Partners?
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