FCAR and FCGR1A

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		FCAR	FCGR1A
Description		Fc fragment of IgA receptor	Fc fragment of IgG receptor Ia
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Specific Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Plasma Membrane Integral Component Of Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane
	Molecular Function	IgA Binding	Transmembrane Signaling Receptor Activity Protein Binding IgG Binding
	Biological Process	Immune Response Neutrophil Degranulation	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Receptor-mediated Endocytosis Phagocytosis, Engulfment Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity
Pathways		Neutrophil degranulation	Cross-presentation of soluble exogenous antigens (endosomes) Cross-presentation of soluble exogenous antigens (endosomes) Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Interferon gamma signaling FCGR3A-mediated IL10 synthesis
Drugs			Cetuximab Etanercept Human immunoglobulin G Gemtuzumab ozogamicin Alemtuzumab Natalizumab Palivizumab Daclizumab Bevacizumab Porfimer sodium Catumaxomab Sarilumab Trastuzumab deruxtecan
Diseases
GWAS		Blood protein levels ( 28240269) Ulcerative colitis ( 28067908)
Interacting Genes		6 interacting genes: CD79A FCGR1A LYN OSCAR PILRA PPP2CA	30 interacting genes: ADIPOQ APCS ASGR1 BIK BMP10 CD163 CLDN19 CLEC7A CRKL CRP FAM3C FCAR FCGR3A HCK HRG ITM2A JAGN1 LAT LHFPL5 LILRB2 MALL NINJ1 NRSN1 RPRM SYK TNMD TSPO2 UPK2 VSTM1 VTI1B
Entrez ID		2204	2209
HPRD ID		00914	00904
Ensembl ID		ENSG00000186431	ENSG00000150337
Uniprot IDs		A0A024R4N4 A0A024R4R4 P24071	P12314
PDB IDs		1OVZ 1OW0 1UCT	3RJD 4W4O 4X4M 4ZNE
Enriched GO Terms of Interacting Partners?
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