FBN2 and MATN2

Data Source:
HPRD (in vitro)

		FBN2	MATN2
Description		fibrillin 2	matrilin 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Microfibril Extracellular Region Extracellular Matrix Collagen-containing Extracellular Matrix	Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Extracellular Matrix Constituent Conferring Elasticity	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding
	Biological Process	Anatomical Structure Morphogenesis Extracellular Matrix Organization Embryonic Limb Morphogenesis Positive Regulation Of Bone Mineralization Sequestering Of TGFbeta In Extracellular Matrix Camera-type Eye Development Positive Regulation Of Osteoblast Differentiation Embryonic Eye Morphogenesis Bone Trabecula Formation	Biological_process
Pathways		Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases		Congenital contractural arachnodactyly (CCA) ; Beals syndrome
GWAS		Atrial fibrillation ( 29892015) Beard thickness ( 26926045) Brain morphology (MOSTest) ( 32665545) Breastfeeding duration ( 25475840) Central corneal thickness ( 32528159) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Height ( 21998595 31562340) Heschl's gyrus morphology ( 25130324) Intraocular pressure ( 29617998) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Multiple system atrophy ( 27629089) Night sleep phenotypes ( 27126917) Obesity (extreme) ( 19553259) Pulse pressure ( 27841878 30578418) Refractive error ( 32231278) Response to fenofibrate (total cholesterol levels) ( 27002377) Severe aplastic anemia ( 32004448) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 28135244 27841878 30578418) Temperament ( 22832960)	Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Diffusing capacity of carbon monoxide ( 30694715) Erectile dysfunction ( 30583798)
Interacting Genes		7 interacting genes: ELN FBN1 LTBP1 MATN2 MFAP2 MFAP5 SMAD2	17 interacting genes: ATXN1 ATXN1L ATXN7 CACNA1A CBFA2T3 COL1A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 DVL3 FBN2 FN1 MATN1 MATN4
Entrez ID		2201	4147
HPRD ID		00416	03660
Ensembl ID		ENSG00000138829	ENSG00000132561
Uniprot IDs		P35556	A0A140VKH7 O00339 Q8N2G3
PDB IDs
Enriched GO Terms of Interacting Partners?
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