FBN2 and DUSP5

Data Source:
BioGRID (proximity labelling technology)

		FBN2	DUSP5
Description		fibrillin 2	dual specificity phosphatase 5
Image		No pdb structure
GO Annotations	Cellular Component	Microfibril Extracellular Region Extracellular Matrix Collagen-containing Extracellular Matrix	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Extracellular Matrix Constituent Conferring Elasticity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/threonine Phosphatase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Mitogen-activated Protein Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Anatomical Structure Morphogenesis Extracellular Matrix Organization Embryonic Limb Morphogenesis Positive Regulation Of Bone Mineralization Sequestering Of TGFbeta In Extracellular Matrix Camera-type Eye Development Positive Regulation Of Osteoblast Differentiation Embryonic Eye Morphogenesis Bone Trabecula Formation	MAPK Cascade Activation Of MAPK Activity Inactivation Of MAPK Activity Endoderm Formation Protein Dephosphorylation Dephosphorylation Peptidyl-tyrosine Dephosphorylation Peptidyl-threonine Dephosphorylation
Pathways		Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres	RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases		Congenital contractural arachnodactyly (CCA) ; Beals syndrome
GWAS		Atrial fibrillation ( 29892015) Beard thickness ( 26926045) Brain morphology (MOSTest) ( 32665545) Breastfeeding duration ( 25475840) Central corneal thickness ( 32528159) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Height ( 21998595 31562340) Heschl's gyrus morphology ( 25130324) Intraocular pressure ( 29617998) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Multiple system atrophy ( 27629089) Night sleep phenotypes ( 27126917) Obesity (extreme) ( 19553259) Pulse pressure ( 27841878 30578418) Refractive error ( 32231278) Response to fenofibrate (total cholesterol levels) ( 27002377) Severe aplastic anemia ( 32004448) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 28135244 27841878 30578418) Temperament ( 22832960)	Crohn's disease ( 23850713) Heel bone mineral density ( 30598549) Lumbar spine bone mineral density (integral) ( 27476799) Non-albumin protein levels ( 29403010) Total body bone mineral density ( 29304378)
Interacting Genes		7 interacting genes: ELN FBN1 LTBP1 MATN2 MFAP2 MFAP5 SMAD2	4 interacting genes: AATK MAPK1 MAPK3 MTDH
Entrez ID		2201	1847
HPRD ID		00416	04349
Ensembl ID		ENSG00000138829	ENSG00000138166
Uniprot IDs		P35556	Q16690
PDB IDs			2G6Z
Enriched GO Terms of Interacting Partners?
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