F11 and TFPI2

Data Source:
HPRD (in vitro)

		F11	TFPI2
Description		coagulation factor XI	tissue factor pathway inhibitor 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Exosome	Extracellular Space Extracellular Matrix
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Heparin Binding Serine-type Aminopeptidase Activity	Serine-type Endopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent
	Biological Process	Blood Coagulation Blood Coagulation, Intrinsic Pathway Plasminogen Activation Positive Regulation Of Fibrinolysis	Blood Coagulation Negative Regulation Of Endopeptidase Activity
Pathways		Intrinsic Pathway of Fibrin Clot Formation Defective F9 activation
Drugs		Coagulation Factor IX (Recombinant) Human C1-esterase inhibitor 3-Hydroxypropyl 3-[(7-carbamimidoyl-1-naphthyl)carbamoyl]benzenesulfonate (1R)-2-[(Diaminomethylene)amino]-1-{4-[(4R)-4-(hydroxymethyl)-1,3,2-dioxaborolan-2-yl]phenyl}ethyl nicotinate (R)-1-(4-(4-(Hydroxymethyl)-1,3,2-dioxaborolan-2-YL)phenethyl)guanidine 6-CARBAMIMIDOYL-4-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-NAPHTHALENE-2-CARBOXYLIC ACID METHYL ESTER (R)-1-(4-(4-(Hydroxymethyl)-1,3,2-dioxaborolan-2-YL)phenyl)guanidine N-(7-CARBAMIMIDOYL-NAPHTHALEN-1-YL)-3-HYDROXY-2-METHYL-BENZAMIDE 4-METHYL-PENTANOIC ACID {1-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYLCARBAMOYL]-2-METHYL-PROPYL}-AMIDE (R)-1-(4-(4-(hydroxymethyl)-1,3,2-dioxaborolan-2-yl)benzyl)guanidine Conestat alfa Thrombin Human thrombin Coagulation Factor IX Human Zinc chloride Zinc sulfate, unspecified form
Diseases		Factor XI deficiency; Plasma thromboplastin antecedent deficiency; Rosenthal syndrome
GWAS		Activated partial thromboplastin time ( 22703881 29403010) Blood protein levels ( 28240269) Cardiac troponin-I levels ( 31014085) Factor XI ( 28053049) Ischemic stroke (cardioembolic) ( 29531354) L-arginine levels ( 27656708) Response to statin therapy ( 20339536) Thrombosis ( 26908601) Venous thromboembolism ( 21980494 23650146 25772935 28373160 31420334 31676865)	Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042)
Interacting Genes		7 interacting genes: F2 GP1BA HGF KNG1 SERPINA5 SERPINF2 TFPI2	5 interacting genes: F11 KLKB1 PLG SKIL SMURF2
Entrez ID		2160	7980
HPRD ID		07524	08962
Ensembl ID		ENSG00000088926	ENSG00000105825
Uniprot IDs		P03951	P48307
PDB IDs		1XX9 1XXD 1XXF 1ZHM 1ZHP 1ZHR 1ZJD 1ZLR 1ZMJ 1ZML 1ZMN 1ZOM 1ZPB 1ZPC 1ZPZ 1ZRK 1ZSJ 1ZSK 1ZSL 1ZTJ 1ZTK 1ZTL 2F83 2FDA 2J8J 2J8L 3BG8 3SOR 3SOS 4CR5 4CR9 4CRA 4CRB 4CRC 4CRD 4CRE 4CRF 4CRG 4D76 4D7F 4D7G 4NA7 4NA8 4TY6 4TY7 4WXI 4X6M 4X6N 4X6O 4X6P 4Y8X 4Y8Y 4Y8Z 5E2O 5E2P 5EOD 5EOK 5EXL 5EXM 5EXN 5I25 5Q0D 5Q0E 5Q0F 5Q0G 5Q0H 5QCK 5QCL 5QCM 5QCN 5QQO 5QQP 5QTT 5QTV 5QTW 5QTY 5TKS 5TKT 5TKU 5WB6 6AOD 6C0S 6HHC 6I58 6R8X 6TS4 6TS5 6TS6 6TS7 6TWB 6USY 6VLU 6VLV 6W50	1ZR0
Enriched GO Terms of Interacting Partners?
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