ETV1 and ATR

Data Source:
BioGRID (affinity chromatography technology, enzymatic study, genetic interference)

		ETV1	ATR
Description		ETS variant transcription factor 1	ATR serine/threonine kinase
Image
GO Annotations	Cellular Component	Chromatin Nucleus	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Golgi Apparatus PML Body
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MutLalpha Complex Binding MutSalpha Complex Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Peripheral Nervous System Neuron Development	DNA Damage Checkpoint Telomere Maintenance DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Multicellular Organism Development Negative Regulation Of DNA Replication Peptidyl-serine Phosphorylation Replication Fork Processing Positive Regulation Of Telomere Maintenance Via Telomerase Cellular Response To UV Interstrand Cross-link Repair Response To Drug Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Autophosphorylation Protein Localization To Chromosome, Telomeric Region Cellular Response To Gamma Radiation Replicative Senescence Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Regulation Of Cellular Response To Heat Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Telomerase Catalytic Core Complex Assembly
Pathways			Meiotic synapsis Activation of ATR in response to replication stress Regulation of HSF1-mediated heat shock response HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases		Ewing's sarcoma Prostate cancer	Alveolar rhabdomyosarcoma Seckel syndrome
GWAS		Blond vs. brown/black hair color ( 30531825) Chronotype ( 30696823) Coronary artery disease ( 29212778) Coronary atherosclerosis (time to event) ( 32589924) Height ( 28552196 31217584) Intraocular pressure ( 30591961) Lymphocyte counts ( 32888494 27863252) Monocyte count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Post bronchodilator FEV1/FVC ratio in smoking ( 30068317) Post bronchodilator percent predicted FEV1 in smoking ( 30068317) Renal underexcretion gout ( 32238385) Type 2 diabetes ( 24509480 32499647 30718926) Verbal declarative memory ( 25648963) White blood cell count ( 32888494)	Eosinophil counts ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 29403010 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 29403010 32888494 27863252) Red cell distribution width ( 32888494 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		19 interacting genes: ATR CCND3 EP300 ERG JUN KAT2B KCNA2 MAPK14 MAPK3 MAPK8 MAPKAPK2 NCOA2 NCOA3 NSMCE2 PRKACA RPS6KA1 RPS6KA5 SPI1 UBE2I	50 interacting genes: AATF ABL1 AP1B1 AP3B1 ARHGEF1 ATM BLM BRCA1 BRCA2 CDKN2C CEP164 CHD4 CHEK1 CHEK2 CHUK CLSPN CREB1 DCAF1 DCLRE1C DTL E2F1 E4F1 EEF1E1 EP300 ETV1 FANCA FANCD2 FANCI FLT1 H2AX KDR LIG4 MCM2 MCPH1 MRE11 MSH2 NBN PA2G4 PIK3CA POLD1 POLN PPP2R3A RAD17 RASSF1 RHEB TP53 TREX1 UPF1 XPA XRCC5
Entrez ID		2115	545
HPRD ID		02765	08369
Ensembl ID		ENSG00000006468	ENSG00000175054
Uniprot IDs		B5MCT2 B7Z2C9 P50549	Q13535
PDB IDs		4AVP 4BNC 5ILS	5YZ0
Enriched GO Terms of Interacting Partners?
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