ESRRB and DLST

Data Source:
BioGRID (proximity labelling technology)

		ESRRB	DLST
Description		estrogen related receptor beta	dihydrolipoamide S-succinyltransferase
Image
GO Annotations	Cellular Component	Chromatin Condensed Chromosome Nucleus Nucleoplasm Cytoplasm Cytosol Integrator Complex	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Membrane Centriolar Satellite Oxoglutarate Dehydrogenase Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Steroid Binding Transcription Factor Binding Zinc Ion Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Dihydrolipoyllysine-residue Succinyltransferase Activity Protein Binding Transferase Activity, Transferring Acyl Groups
	Biological Process	Embryonic Placenta Development Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Stem Cell Division Stem Cell Population Maintenance Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Cell Dedifferentiation Photoreceptor Cell Maintenance Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Inner Ear Development Positive Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Transcription Involved In G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Division Negative Regulation Of Stem Cell Differentiation	Generation Of Precursor Metabolites And Energy Tricarboxylic Acid Cycle 2-oxoglutarate Metabolic Process Succinyl-CoA Metabolic Process Lysine Catabolic Process Protein Phosphopantetheinylation L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Histone Succinylation
Pathways		Nuclear Receptor transcription pathway	Glyoxylate metabolism and glycine degradation Lysine catabolism Citric acid cycle (TCA cycle)
Drugs		Diethylstilbestrol Genistein Flavone
Diseases
GWAS		Maximal oxygen uptake response ( 25729143) Sphingomyelin 24:0 levels ( 31560688) Tuberculosis ( 30287856)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Depression ( 29700475) Eosinophil counts ( 32888494) Mood instability ( 29187730) Non-small cell lung cancer ( 23144319)
Interacting Genes		8 interacting genes: ESRRG HIF1A HSP90AA1 HSP90AB1 NCOA2 NCOA3 NRIP1 SP1	16 interacting genes: ARIH2 CCDC86 DLG5 FLII NAP1L1 NDRG1 OGDH PAK4 PFN2 RUSC2 SCFD1 TUBB4B UBE2D2 UMPS ZBTB16 ZHX1
Entrez ID		2103	1743
HPRD ID		03700	00520
Ensembl ID		ENSG00000119715	ENSG00000119689
Uniprot IDs		O95718	A0A024R6C9 B7Z6J1 P36957
PDB IDs		1LO1 6LIT 6LN4	6H05
Enriched GO Terms of Interacting Partners?
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