ESR2 and SYNE2

Data Source:
BioGRID (biochemical)

		ESR2	SYNE2
Description		estrogen receptor 2	spectrin repeat containing nuclear envelope protein 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Mitochondrion	Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Cytoplasm Mitochondrion Focal Adhesion Integral Component Of Membrane Sarcoplasmic Reticulum Z Disc Lamellipodium Membrane Filopodium Membrane Nuclear Membrane Nuclear Lumen Sarcoplasmic Reticulum Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Intermediate Filament Cytoskeleton Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Steroid Hormone Receptor Activity Nuclear Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Enzyme Binding Estrogen Receptor Activity Estrogen Response Element Binding Identical Protein Binding Receptor Antagonist Activity	Actin Binding Protein Binding Actin Filament Binding Cytoskeleton-nuclear Membrane Anchor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Cell-cell Signaling Negative Regulation Of Cell Growth Intracellular Steroid Hormone Receptor Signaling Pathway Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of DNA-binding Transcription Factor Activity Cellular Response To Estradiol Stimulus Negative Regulation Of Signaling Receptor Activity	Nuclear Migration Nucleokinesis Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Positive Regulation Of Cell Migration Nuclear Migration Along Microfilament Centrosome Localization Regulation Of Cilium Assembly
Pathways		PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Nuclear Receptor transcription pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ESR-mediated signaling Extra-nuclear estrogen signaling	Meiotic synapsis
Drugs		Diethylstilbestrol Conjugated estrogens Progesterone Raloxifene Estrone Tamoxifen Estradiol Trilostane Estramustine Oxybenzone Genistein Prasterone Benzophenone Phthalic Acid Pyrazole Para-Mercury-Benzenesulfonic Acid Naringenin ICI-164384 5-Alpha-Androstane-3-Beta,17beta-Diol 4-(2-{[4-{[3-(4-Chlorophenyl)Propyl]Sulfanyl}-6-(1-Piperazinyl)-1,3,5-Triazin-2-Yl]Amino}Ethyl)Phenol Quercetin Afimoxifene Estriol Estrone sulfate MF101 CHF 4227 TAS-108 Lasofoxifene Arzoxifene Bazedoxifene Prinaberel ERB-196 [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE 4-(6-HYDROXY-BENZO[D]ISOXAZOL-3-YL)BENZENE-1,3-DIOL 2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL 2-(4-HYDROXY-PHENYL)BENZOFURAN-5-OL (3aS,4R,9bR)-2,2-difluoro-4-(4-hydroxyphenyl)-6-(methoxymethyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL 17alpha-Estriol (9aS)-4-bromo-9a-butyl-7-hydroxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one Erteberel (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL Eugenol Octocrylene Enzacamene Equol 2-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenol Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate Estriol tripropionate Fluoroestradiol F-18
Diseases			Emery-Dreifuss muscular dystrophy
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Atrial fibrillation ( 30061737) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Depression ( 29700475) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Metabolite levels ( 23823483) Prostate cancer ( 26443449) Red blood cell count ( 32888494 27863252)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Atrial fibrillation ( 28416818 30061737 29892015 22544366) Blond vs. brown/black hair color ( 30531825) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Depression ( 29700475) HDL cholesterol levels ( 32109663) Metabolite levels ( 23823483) Nevus count or cutaneous melanoma ( 32341527 30429480) PR interval ( 32439900) Psoriasis ( 25854761) Pulmonary function decline ( 22424883) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite ratios in chronic kidney disease ( 29545352) Sphingomyelin levels ( 31551469) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		104 interacting genes: AGR3 AKAP13 AKT1 ARID5A BCAS2 CALM1 CALM2 CALM3 CASC3 CASZ1 CCNC CDK8 CYSRT1 DAP3 DDX54 DKK3 DNMT3L DNTTIP2 EP300 ESR1 HOXA1 IL13RA2 IL24 ITIH5 JMJD1C KAT5 KLK9 KPNA3 KPRP KRTAP6-2 LCK LRATD2 MAD2L1 MAPK1 MAPK11 MED1 MED10 MED12 MED14 MED16 MED17 MED20 MED21 MED23 MED24 MED6 MED7 MEOX2 MKNK2 MMS19 MRC2 MSH2 NCOA1 NCOA2 NCOA3 NCOA6 NCOA7 NCOR1 NCOR2 NFKBIB NFKBID NOTCH2NLA NR0B1 NR0B2 NRIP1 OXT PELP1 PIAS1 PIAS2 PIAS3 PLSCR1 PNRC1 PNRC2 PPARGC1A PPP5C PRMT2 PRSS50 PSMC3IP PSMC5 RBFOX2 RBM39 REXO4 RFX6 SERPINH1 SMAD2 SMAD3 SMAD4 SMARCE1 SP1 SRA1 SRC SREBF1 STAT5A TFF1 TRAM1 TRIM24 TRIM59 TRIP4 TXNRD1 WIPI1 YWHAH YWHAQ ZBTB17 ZNHIT3	11 interacting genes: ABI1 ACTC1 BRAP CALM1 MAPK3 MAPK8IP2 MEOX2 MTNR1B PML SASH1 UBC
Entrez ID		2100	23224
HPRD ID		03390	09763
Ensembl ID		ENSG00000140009	ENSG00000054654
Uniprot IDs		A0A348FV93 F1D8N3 Q0PTK2 Q7LCB3 Q92731	Q6MZP0 Q8WXH0
PDB IDs		1L2J 1NDE 1QKM 1U3Q 1U3R 1U3S 1U9E 1X76 1X78 1X7B 1X7J 1YY4 1YYE 1ZAF 2FSZ 2GIU 2I0G 2JJ3 2NV7 2QTU 2YJD 2YLY 2Z4B 3OLL 3OLS 3OMO 3OMP 3OMQ 4J24 4J26 4ZI1 5TOA	4DXS 4FI9
Enriched GO Terms of Interacting Partners?
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