EYA4 and AATK

Data Source:
BioGRID (two hybrid)

		EYA4	AATK
Description		EYA transcriptional coactivator and phosphatase 4	apoptosis associated tyrosine kinase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Cellular_component Integral Component Of Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Metal Ion Binding	Protein Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	DNA Repair Multicellular Organism Development Visual Perception Sensory Perception Of Sound Anatomical Structure Morphogenesis Histone Dephosphorylation Cell Differentiation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of DNA Repair Anatomical Structure Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Protein Phosphorylation Brain Development Biological_process Peptidyl-tyrosine Autophosphorylation
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases
GWAS		Adverse response to drug ( 30420678) Atrial fibrillation ( 29892015) Bone mineral density (paediatric, skull) ( 24945404) Estimated glomerular filtration rate ( 31152163 31015462) Facial morphology traits (63 three-dimensional facial segments) ( 29459680) Glomerular filtration rate (creatinine) ( 28452372) Heel bone mineral density ( 30598549 28869591) Hip circumference ( 28552196) Hip circumference adjusted for BMI ( 28552196) Methadone dose in opioid dependence ( 28115739) Neutrophil count ( 32888494) Protein quantitative trait loci ( 18464913) Response to angiotensin II receptor blocker therapy ( 22566498) Triglyceride levels ( 32203549 32154731) Visceral fat ( 22589738) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) White blood cell count ( 32888494)	Appendicular lean mass ( 33097823) Beef consumption ( 32066663) Lymphocyte percentage of white cells ( 32888494) Neuroticism ( 29255261) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		3 interacting genes: AATK ERBB3 SIX1	43 interacting genes: BDKRB2 CDC14A CDC25B CDK5 DUSP1 DUSP14 DUSP29 DUSP5 DUSP6 DUSP9 ERBB2 EYA2 EYA4 ILKAP MTMR10 MTMR6 MTMR8 MTMR9 PPM1A PPM1B PPM1F PPM1K PPM1M PPP1CA PPP1CB PPP1CC PPP3CA PPP3CB PTEN PTPDC1 PTPN11 PTPN12 PTPN18 PTPN20 PTPN6 PTPN7 PTPRR SBF1 STK39 STYX TAB1 TEPSIN TPTE2
Entrez ID		2070	9625
HPRD ID		04648	05591
Ensembl ID		ENSG00000112319	ENSG00000181409
Uniprot IDs		A0A0S2Z3Q2 A0A0S2Z3V9 B4DIV6 B4DRQ6 F2Z2Y1 O95677 Q96CJ7	H7C175 Q6ZMQ8
PDB IDs
Enriched GO Terms of Interacting Partners?
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