EPOR and IRS2

Data Source:
HPRD (in vivo)

		EPOR	IRS2
Description		erythropoietin receptor	insulin receptor substrate 2
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Nuclear Speck	Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	Erythropoietin Receptor Activity Protein Binding Identical Protein Binding	Insulin Receptor Binding Protein Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Phosphatidylinositol 3-kinase Binding 14-3-3 Protein Binding
	Biological Process	Signal Transduction Brain Development Heart Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Erythropoietin-mediated Signaling Pathway Positive Regulation Of Ras Protein Signal Transduction Decidualization	MAPK Cascade Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of B Cell Apoptotic Process Glucose Metabolic Process Signal Transduction Axon Guidance Brain Development Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Response To Glucose Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Lipid Metabolic Process Positive Regulation Of Cell Migration Mammary Gland Development Positive Regulation Of B Cell Proliferation Positive Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Insulin Secretion Cellular Response To Insulin Stimulus Negative Regulation Of Kinase Activity Interleukin-7-mediated Signaling Pathway Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Positive Regulation Of Ras Protein Signal Transduction Phosphatidylinositol-mediated Signaling Positive Regulation Of Protein Kinase B Signaling Lipid Homeostasis Cellular Response To Glucose Stimulus
Pathways		Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS	PI3K Cascade IRS-mediated signalling SOS-mediated signalling SOS-mediated signalling PIP3 activates AKT signaling Interleukin-7 signaling PI3K/AKT activation PI3K/AKT activation Constitutive Signaling by Aberrant PI3K in Cancer IRS-related events triggered by IGF1R Signaling by Leptin RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation RET signaling Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS Growth hormone receptor signaling
Drugs		Darbepoetin alfa Erythropoietin Dibromotyrosine Peginesatide Methoxy polyethylene glycol-epoetin beta
Diseases		Congenital polycythemia; Familial erythrocytosis (ECYT)
GWAS		Coronary artery disease ( 29212778) Serum erythropoietin levels ( 30271932)	Antipsychotic drug-induced weight gain in schizophrenia ( 31447353) Heel bone mineral density ( 30598549 28869591) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Insulin-related traits (multivariate analysis) ( 32002517) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Nose size ( 27182965) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Platelet count ( 29403010) Prostate cancer ( 29117387) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252) Type 2 diabetes ( 30297969) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White matter lesion progression ( 26451028) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)
Interacting Genes		39 interacting genes: ATXN2L CBL CISH CRKL CSF2RB EGLN3 ELOB ELOC EPO GAB1 GAB2 GNAI1 GRAP GRB2 INPP5D IRS2 JAK2 KIT KITLG KLK3 LYN MAPK1 MAPK3 MST1R PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 RACK1 SH2B2 SHC1 SOCS2 SOCS3 STAT5A STAT5B SYK VAV1 VHL	40 interacting genes: ATP2A1 ATP2A2 BCL2L1 CRK EPOR FES GRB2 IGF1R IL4R INSR JAK1 JAK2 JAK3 MPL MTDH NEDD4 NTRK1 PIK3CA PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PTPN11 PTPN6 PTPRF RPTOR SHC1 SOCS1 SOCS3 SOCS6 SOCS7 SRPK2 TYK2 UBTF YWHAB YWHAE YWHAG YWHAQ YWHAZ
Entrez ID		2057	8660
HPRD ID		00587	02878
Ensembl ID		ENSG00000187266	ENSG00000185950
Uniprot IDs		P19235	Q9P084 Q9Y4H2
PDB IDs		1CN4 1EBA 1EBP 1EER 1ERN 2JIX 2MV6 4Y5V 4Y5X 4Y5Y 6E2Q 6MOE 6MOF 6MOH 6MOI 6MOJ 6MOK 6MOL	3FQW 3FQX
Enriched GO Terms of Interacting Partners?
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