EPHB1 and GM2A

Data Source:
BioGRID (affinity chromatography technology)

		EPHB1	GM2A
Description		EPH receptor B1	GM2 ganglioside activator
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GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Cytosol Plasma Membrane Integral Component Of Plasma Membrane Dendrite Early Endosome Membrane Neuron Projection Receptor Complex Extracellular Exosome	Extracellular Region Cytosol Cytoplasmic Side Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Azurophil Granule Lumen Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding	Lipid Transporter Activity Phospholipase Activator Activity Sphingolipid Activator Protein Activity Beta-N-acetylgalactosaminidase Activity
	Biological Process	Angiogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Skeletal Muscle Satellite Cell Activation Peptidyl-tyrosine Phosphorylation Central Nervous System Projection Neuron Axonogenesis Neurogenesis Establishment Of Cell Polarity Retinal Ganglion Cell Axon Guidance Cell-substrate Adhesion Positive Regulation Of Kinase Activity Regulation Of JNK Cascade Protein Autophosphorylation Ephrin Receptor Signaling Pathway Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Synapse Assembly Cell Chemotaxis Dendritic Spine Development Dendritic Spine Morphogenesis Neural Precursor Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Regulation Of Neuron Death Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Satellite Cell Differentiation	Glycosphingolipid Metabolic Process Ganglioside Catabolic Process Lipid Transport Learning Or Memory Oligosaccharide Catabolic Process Lipid Storage Neutrophil Degranulation Neuromuscular Process Controlling Balance Positive Regulation Of Hydrolase Activity
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells	Glycosphingolipid metabolism Neutrophil degranulation
Drugs		Fostamatinib	Platelet Activating Factor Lauric acid Lpc-Ether Choline alfoscerate Myristic acid
Diseases			GM2 gangliosidoses, including: Tay-Sachs disease (type I); Sandhoff disease (type II); Tay-Sachs disease AB variant
GWAS		Adult body size ( 32376654) Bitter beverage consumption ( 31046077) CV-A6-associated hand, foot, and mouth disease (severe vs mild) ( 32634583) Daytime sleep phenotypes ( 27126917) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Familial lung adenocarcinoma ( 29924316) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Iron status biomarkers (total iron binding capacity) ( 28334935) Mood instability ( 31168069) Neurofibrillary tangles ( 31497858) Small cell lung carcinoma ( 28604730) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)	Bulimia nervosa ( 23568457) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Serum folate levels ( 29953918)
Interacting Genes		13 interacting genes: ACP1 EFNA1 EFNA5 EFNB1 EFNB2 EPHB6 ERBB2 GRB10 GRB2 MTDH NCK1 PRKCG PXN	3 interacting genes: GPLD1 HEXA PLD2
Entrez ID		2047	2760
HPRD ID		02790	02034
Ensembl ID		ENSG00000154928	ENSG00000196743
Uniprot IDs		P54762	P17900
PDB IDs		2DJS 2EAO 3ZFX 5MJA 5MJB 6UMW	1G13 1PU5 1PUB 1TJJ 2AF9 2AG2 2AG4 2AG9
Enriched GO Terms of Interacting Partners?
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