DHFR2 and ARL13B

Data Source:
BioGRID (genetic interference)

		DHFR2	ARL13B
Description		dihydrofolate reductase 2	ADP ribosylation factor like GTPase 13B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix	Cilium Motile Cilium Ciliary Membrane Non-motile Cilium
	Molecular Function	MRNA Binding Dihydrofolate Reductase Activity NADP Binding	Protein Binding GTP Binding
	Biological Process	Glycine Biosynthetic Process One-carbon Metabolic Process Thymidine Biosynthetic Process Dihydrofolate Metabolic Process Tetrahydrofolate Metabolic Process Tetrahydrofolate Biosynthetic Process Folic Acid Metabolic Process	Smoothened Signaling Pathway Neural Tube Patterning Interneuron Migration From The Subpallium To The Cortex Formation Of Radial Glial Scaffolds Cilium Assembly Receptor Localization To Non-motile Cilium Non-motile Cilium Assembly
Pathways		Metabolism of folate and pterines	ARL13B-mediated ciliary trafficking of INPP5E Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy
Drugs		5-Chloryl-2,4,6-quinazolinetriamine 5-[4-Tert-Butylphenylsulfanyl]-2,4-Quinazolinediamine 5-(4-Morpholin-4-Yl-Phenylsulfanyl)-2,4-Quinazolinediamine 5-(4-Methoxyphenoxy)-2,4-Quinazolinediamine 5-Phenylsulfanyl-2,4-Quinazolinediamine 5-[(4-Methylphenyl)Sulfanyl]-2,4-Quinazolinediamine 7-(1-ETHYL-PROPYL)-7H-PYRROLO-[3,2-F]QUINAZOLINE-1,3-DIAMINE 7-[2-METHOXY-1-(METHOXYMETHYL)ETHYL]-7H-PYRROLO[3,2-F] QUINAZOLINE-1,3-DIAMINE Epigallocatechin gallate
Diseases			Joubert syndrome
GWAS
Interacting Genes		1 interacting genes: TINF2	130 interacting genes: ACSF2 AIG1 ALG3 ANKRD46 AOC3 AQP10 B4GALNT2 BMP10 BNIP3 BRICD5 C1GALT1 C2CD2L C4orf3 CCDC167 CCL4 CCL4L2 CD151 CD302 CD53 CDIPT CFHR5 CLDN4 CLDN8 CLEC4G CLEC7A CLN6 CMTM3 CMTM7 COL8A2 CSGALNACT2 CTSA CXCL16 CYB561D2 EBP EMP1 ENTPD3 FAXDC2 FDFT1 FKBP8 FUNDC2 FXYD6 GAD2 GIMAP1 GIMAP5 GJB2 GOSR2 GPR37L1 HMOX1 HMOX2 HOMER3 ICMT ITGAM JAGN1 KCNJ2 KLRG1 LEPROTL1 LPAR3 MAL2 MALL MMD MOSPD3 MUCL1 MYADML2 NAT8 NINJ2 NKG7 NRM NUCB2 ORMDL1 ORMDL3 PAEP PDZK1IP1 PGAP2 PLN PLP1 PLPP4 PLPPR2 PMP22 PRB1 PTPN9 RTP2 S100A2 SACM1L SEMA4G SLC13A3 SLC2A5 SLC35A1 SLC35B1 SLC38A7 SLC39A2 SMAGP SPN STRIT1 STX1A STX7 TECR TEX264 TFRC THSD7A THSD7B TM6SF2 TMEM11 TMEM121 TMEM128 TMEM14C TMEM187 TMEM190 TMEM218 TMEM229B TMEM254 TMEM43 TMEM54 TMEM65 TMEM79 TMEM86B TMEM97 TMUB2 TNFRSF10C TNMD TRARG1 TSPO2 UBE2I VAMP1 VAMP2 VAMP3 VAMP4 VSTM1 WFDC2 YIPF6 ZDHHC15
Entrez ID		200895	200894
HPRD ID		11246	12334
Ensembl ID		ENSG00000178700	ENSG00000169379
Uniprot IDs		Q86XF0	Q3SXY8
PDB IDs
Enriched GO Terms of Interacting Partners?
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