CRTC2 and SIK3

Data Source:
HPRD (in vitro, in vivo)

		CRTC2	SIK3
Description		CREB regulated transcription coactivator 2	SIK family kinase 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Extracellular Exosome	Cytoplasm
	Molecular Function	Chromatin Binding Protein Binding CAMP Response Element Binding Protein Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Tau-protein Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Gluconeogenesis Viral Process Positive Regulation Of CREB Transcription Factor Activity Glucose Homeostasis Histone H3-K9 Acetylation Positive Regulation Of Transcription By RNA Polymerase II Protein Homotetramerization Toxin Transport	Microtubule Cytoskeleton Organization Protein Phosphorylation Intracellular Signal Transduction Positive Regulation Of TORC1 Signaling Positive Regulation Of TORC2 Signaling
Pathways		Transcriptional activation of mitochondrial biogenesis Circadian Clock
Drugs			Fostamatinib
Diseases
GWAS		Age at first birth ( 27798627) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cooked vegetable consumption ( 32066663) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Empathy quotient ( 29527006) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Raw vegetable consumption ( 32066663) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Allergic rhinitis ( 30013184) Apolipoprotein B levels ( 32203549) Blood protein levels ( 28240269) Body mass index ( 31978080) Cholesterol ( 31902109) Delirium ( 29631748) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494 27863252) HDL cholesterol ( 31170924 24886709) HDL cholesterol levels ( 32203549) Hearing function ( 25060954) Mean platelet volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Metabolic syndrome ( 30382898) Non-accommodative esotropia ( 30098192) Platelet count ( 32888494) Red cell distribution width ( 32888494) Refractive error ( 32231278) Response to Vitamin E supplementation ( 22437554) Sum eosinophil basophil counts ( 27863252) Triglyceride levels ( 32203549 29615537) Triglycerides ( 24886709)
Interacting Genes		14 interacting genes: ATPAF2 CCDC57 CDC23 CREB1 MFHAS1 PPP3CA PRKAA1 SIK1 SIK2 SIK3 SUFU YWHAB YWHAG YWHAZ	6 interacting genes: CRTC2 HDAC5 PRKACA TRAF1 TRIP6 YWHAZ
Entrez ID		200186	23387
HPRD ID		12347	11121
Ensembl ID		ENSG00000160741	ENSG00000160584
Uniprot IDs		Q53ET0	A1A5A9 Q9Y2K2
PDB IDs		4HTM
Enriched GO Terms of Interacting Partners?
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