MLKL and PMFBP1

Data Source:
BioGRID (affinity chromatography technology)

		MLKL	PMFBP1
Description		mixed lineage kinase domain like pseudokinase	polyamine modulated factor 1 binding protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cell Junction	Cytoplasm Sperm Connecting Piece
	Molecular Function	Protein Kinase Activity JUN Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein-containing Complex Binding	Molecular_function
	Biological Process	Protein Phosphorylation Cell Surface Receptor Signaling Pathway Activation Of JNKK Activity Activation Of JUN Kinase Activity Defense Response To Virus Protein Homotrimerization Necroptotic Process Necroptotic Signaling Pathway Execution Phase Of Necroptosis	Spermatogenesis
Pathways		TRP channels RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Microbial modulation of RIPK1-mediated regulated necrosis
Drugs
Diseases
GWAS		Testicular germ cell tumor ( 23666239)	Adult body size ( 32376654) Age at first sexual intercourse ( 27089180) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30679032) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 28240269) Body mass index (change over time) in cancer ( 28044437) Body mass index (change over time) in cancer or chronic obstructive pulmonary disease ( 28044437) Chronotype ( 30696823) Depression ( 29700475) Hemoglobin levels ( 32327693) LDL cholesterol levels ( 32203549) Liver enzyme levels (alkaline phosphatase) ( 22001757) Low density lipoprotein cholesterol levels ( 31217584) Lung function (FVC) ( 30061609) Mean reticulocyte volume ( 32888494) Morning person ( 30696823) Offspring birth weight ( 31043758) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Serum alkaline phosphatase levels ( 31666285) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 31217584) Triglyceride levels ( 32203549)
Interacting Genes		7 interacting genes: ANAPC11 CDK1 NDUFB7 PSMB1 RAD18 S100A10 THOC3
Entrez ID		197259	83449
HPRD ID		08752	10157
Ensembl ID		ENSG00000168404	ENSG00000118557
Uniprot IDs		Q8NB16	Q8TBY8
PDB IDs		2MSV 4M67 4MWI 5KNJ 5KO1 6BWK 6D74 6O5Z 6UX8
Enriched GO Terms of Interacting Partners?
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