EEF1A2 and CHRM4

Data Source:
HPRD (in vitro, in vivo)

		EEF1A2	CHRM4
Description		eukaryotic translation elongation factor 1 alpha 2	cholinergic receptor muscarinic 4
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Eukaryotic Translation Elongation Factor 1 Complex Neuronal Cell Body Synapse Cytoplasmic Side Of Lysosomal Membrane	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse Postsynaptic Membrane
	Molecular Function	Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding Translation Factor Activity, RNA Binding Protein Kinase Binding	G Protein-coupled Serotonin Receptor Activity Protein Binding G Protein-coupled Acetylcholine Receptor Activity Neurotransmitter Receptor Activity
	Biological Process	Translation Translational Elongation Response To Inorganic Substance Positive Regulation Of Apoptotic Process Response To Electrical Stimulus Positive Regulation Of Lipid Kinase Activity Regulation Of Chaperone-mediated Autophagy	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Locomotion G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways		Eukaryotic Translation Elongation	Muscarinic acetylcholine receptors G alpha (i) signalling events
Drugs			Ziprasidone Amitriptyline Olanzapine Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Procyclidine Loxapine Carbamoylcholine Hyoscyamine Meperidine Imipramine Darifenacin Nortriptyline Amoxapine Cinnarizine Atropine Nicardipine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Propiomazine Tropicamide Brompheniramine Maprotiline Methantheline Bethanechol Tolterodine Promethazine Pilocarpine Doxepin Desipramine Ketamine Quetiapine Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin Isopropamide Acetylcholine ALKS 27 Fesoterodine Hexocyclium Aclidinium Umeclidinium Trimebutine Dosulepin Etoperidone Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Prostate cancer ( 23535732)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 28991256 29483656)
Interacting Genes		10 interacting genes: ABTB1 CHRM4 ERG MAPK6 SMN1 STK11 SUMO2 TPT1 TSPY1 TTLL12	20 interacting genes: B2M CBFA2T3 CD59 CD81 EEF1A2 ERGIC3 GPRASP1 GRB2 MCL1 METTL9 MFSD4A QSOX1 RAB3A RHBDD2 RTN4 SMIM7 SYN2 TM7SF2 TSPAN7 YIPF3
Entrez ID		1917	1132
HPRD ID		04265	00330
Ensembl ID		ENSG00000101210	ENSG00000180720
Uniprot IDs		Q05639	P08173
PDB IDs		3C5J	5DSG 6D9H 6KP6
Enriched GO Terms of Interacting Partners?
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