EDN3 and CTSE

Data Source:
HPRD (in vitro)

		EDN3	CTSE
Description		endothelin 3	cathepsin E
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Endosome
	Molecular Function	Signaling Receptor Binding Hormone Activity Endothelin B Receptor Binding	Aspartic-type Endopeptidase Activity Peptidase Activity Identical Protein Binding
	Biological Process	Neural Crest Cell Migration Positive Regulation Of Leukocyte Chemotaxis Regulation Of Systemic Arterial Blood Pressure By Endothelin Cellular Calcium Ion Homeostasis Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Multicellular Organism Development Blood Circulation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Heart Rate Regulation Of Gene Expression Cellular Magnesium Ion Homeostasis Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Regulation Of Vasoconstriction Peptide Hormone Secretion Neuron Differentiation Melanocyte Differentiation Neutrophil Chemotaxis Vasoconstriction Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cell Differentiation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Hormone Secretion Inositol Phosphate-mediated Signaling Regulation Of Developmental Pigmentation Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Positive Regulation Of Potassium Ion Transmembrane Transport	Proteolysis Protein Autoprocessing Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	MHC class II antigen presentation
Drugs
Diseases		Hirschsprung disease (HD) Congenital central hypoventilation syndrome (CCHS) Waardenburg syndrome (WS)
GWAS		Blood pressure ( 21909110) Diastolic blood pressure ( 21909115 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Hypertension ( 19430479 21909115) Metabolite levels ( 23823483) Response to diuretic therapy in hypertension ( 23753411) Systolic blood pressure ( 21909115 28739976 27618447 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858)
Interacting Genes		5 interacting genes: CMA1 CTSE EDNRA EDNRB KEL	5 interacting genes: A2M BAG6 EDN3 EMG1 INS
Entrez ID		1908	1510
HPRD ID		00570	00294
Ensembl ID		ENSG00000124205	ENSG00000196188
Uniprot IDs		P14138 Q4FAT2	B4DNU8 P14091
PDB IDs		6IGK	1LCG 1TZS
Enriched GO Terms of Interacting Partners?
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