APLNR and GJB2

Data Source:
BioGRID (two hybrid)

		APLNR	GJB2
Description		apelin receptor	gap junction protein beta 2
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Integral Component Of Plasma Membrane Gap Junction Connexin Complex Lateral Plasma Membrane Cell Body Perinuclear Region Of Cytoplasm Astrocyte Projection
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Signaling Receptor Activity Apelin Receptor Activity	Gap Junction Channel Activity Calcium Ion Binding Protein Binding Identical Protein Binding Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling
	Biological Process	Angiogenesis Blood Vessel Development Vasculogenesis G Protein-coupled Receptor Signaling Pathway Gastrulation Heart Development Adult Heart Development Viral Process Negative Regulation Of CAMP-mediated Signaling Positive Regulation Of Angiogenesis Regulation Of Body Fluid Levels Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Apelin Receptor Signaling Pathway Coronary Vasculature Development Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Inhibitory G Protein-coupled Receptor Phosphorylation	Response To Ischemia Cell-cell Signaling Aging Sensory Perception Of Sound Cell Communication By Electrical Coupling Gap Junction Assembly Response To Estradiol Response To Lipopolysaccharide Response To Retinoic Acid Response To Progesterone Cellular Response To Oxidative Stress Response To Human Chorionic Gonadotropin Response To Antibiotic Decidualization Inner Ear Development Transmembrane Transport Cellular Response To Glucagon Stimulus Cellular Response To Dexamethasone Stimulus Epididymis Development Gap Junction-mediated Intercellular Transport
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Gap junction assembly Transport of connexons to the plasma membrane
Drugs
Diseases			Keratitis-ichthyosis-deafness syndrome Palmoplantar keratoderma with deafness Deafness, autosomal dominant Deafness, autosomal recessive Vohwinkel syndrome, including: Vohwinkel syndrome (VS); Vohwinkel syndrome with ichthyosis
GWAS			Facial emotion recognition (happy faces) ( 28608620)
Interacting Genes		8 interacting genes: AKR1B1 APLN GJB2 LAMP2 MARK4 MTCH1 NDRG4 SETD3	43 interacting genes: AMIGO1 APLNR AQP6 ARL13B CAV1 CD14 CNST CREB3 EBP ERGIC3 FAM209A FFAR2 GJA5 GJA8 GJB1 GJB6 GPR152 GPR42 HSD17B13 KCNK5 KLRC1 LHFPL5 LMNA LRRC4C MFSD6 MS4A6E PEX12 PLEKHB2 SAR1A SHISAL1 SLC18A1 SLC30A2 SSMEM1 TBXA2R TEX29 TIMMDC1 TLCD4 TM2D2 TMEM106A TMEM237 TMEM31 TMX2 TRHR
Entrez ID		187	2706
HPRD ID		02503	00413
Ensembl ID		ENSG00000134817	ENSG00000165474
Uniprot IDs		B2RDH3 B3KQN4 P35414	H9U1J4 P29033
PDB IDs		2LOT 2LOU 2LOV 2LOW 5VBL 6KNM	1XIR 2ZW3 3IZ1 3IZ2 5ER7 5ERA 5KJ3 5KJG 6UVR 6UVS 6UVT
Enriched GO Terms of Interacting Partners?
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