DUSP6 and NTN4

Data Source:
HPRD (in vitro)

		DUSP6	NTN4
Description		dual specificity phosphatase 6	netrin 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Plasma Membrane Laminin Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/threonine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Mitogen-activated Protein Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Protein Binding Laminin-1 Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Inactivation Of MAPK Activity Protein Dephosphorylation Response To Organic Cyclic Compound Cell Differentiation Peptidyl-tyrosine Dephosphorylation Peptidyl-threonine Dephosphorylation Response To Drug Positive Regulation Of Apoptotic Process Response To Nitrosative Stress Regulation Of Heart Growth Negative Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor	Axon Guidance Animal Organ Morphogenesis Tissue Development Neuron Remodeling Cell Migration Substrate Adhesion-dependent Cell Spreading Regulation Of Branching Involved In Salivary Gland Morphogenesis By Extracellular Matrix-epithelial Cell Signaling Basement Membrane Assembly
Pathways		RAF-independent MAPK1/3 activation ERKs are inactivated Negative regulation of MAPK pathway Signaling by MAPK mutants	Non-integrin membrane-ECM interactions Netrin-1 signaling
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 29325848 30478444) Night sleep phenotypes ( 27126917)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Allergic dermatitis (nickel) ( 23921680) Blood protein levels ( 30072576 29875488) BRCA1/2-negative high-risk breast cancer ( 30323354) Breast cancer ( 29059683 23535729 23535733) Breast size ( 27182965) Diastolic blood pressure ( 30224653) Diffusing capacity of carbon monoxide ( 30694715) Refractive error ( 32231278)
Interacting Genes		12 interacting genes: AATK ERBB4 LMTK2 LTK MAPK1 MAPK3 MDFI ROR2 SRPK1 TEX11 TXK ZNF212	13 interacting genes: ADAMTSL4 CASK CYSRT1 HOXA1 KPRP KRTAP10-8 KRTAP21-2 KRTAP5-9 LCE1C MEOX2 NBPF19 NOTCH2NLA PLSCR1
Entrez ID		1848	59277
HPRD ID		04124	10121
Ensembl ID		ENSG00000139318	ENSG00000074527
Uniprot IDs		A0A024RBC1 Q16828 Q53GP9	A8K3H6 B2RE43 Q9HB63
PDB IDs		1HZM 1MKP
Enriched GO Terms of Interacting Partners?
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