DUSP6 and CHRNE

Data Source:
BioGRID (genetic interference)

		DUSP6	CHRNE
Description		dual specificity phosphatase 6	cholinergic receptor nicotinic epsilon subunit
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Neuromuscular Junction Neuron Projection Synapse Postsynaptic Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/threonine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Mitogen-activated Protein Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Cation Transmembrane Transporter Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	MAPK Cascade Activation Of MAPK Activity Inactivation Of MAPK Activity Protein Dephosphorylation Response To Organic Cyclic Compound Cell Differentiation Peptidyl-tyrosine Dephosphorylation Peptidyl-threonine Dephosphorylation Response To Drug Positive Regulation Of Apoptotic Process Response To Nitrosative Stress Regulation Of Heart Growth Negative Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor	Muscle Contraction Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Ion Transmembrane Transport Regulation Of Membrane Potential Nervous System Process Excitatory Postsynaptic Potential Cation Transmembrane Transport
Pathways		RAF-independent MAPK1/3 activation ERKs are inactivated Negative regulation of MAPK pathway Signaling by MAPK mutants	Highly sodium permeable postsynaptic acetylcholine nicotinic receptors
Drugs
Diseases			Congenital myasthenic syndrome
GWAS		Attention deficit hyperactivity disorder ( 29325848 30478444) Night sleep phenotypes ( 27126917)	Platelet count ( 29403010)
Interacting Genes		12 interacting genes: AATK ERBB4 LMTK2 LTK MAPK1 MAPK3 MDFI ROR2 SRPK1 TEX11 TXK ZNF212	1 interacting genes: CHRNA1
Entrez ID		1848	1145
HPRD ID		04124	00008
Ensembl ID		ENSG00000139318	ENSG00000108556
Uniprot IDs		A0A024RBC1 Q16828 Q53GP9	Q04844
PDB IDs		1HZM 1MKP	2DF9
Enriched GO Terms of Interacting Partners?
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