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TSC22D3 and NFKB2
Data Source:
BioGRID
(affinity chromatography technology, pull down)
HPRD
(in vivo, in vitro)
TSC22D3
NFKB2
Description
TSC22 domain family member 3
nuclear factor kappa B subunit 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytosol
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Bcl3/NF-kappaB2 Complex
Molecular Function
Protein Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Regulation Of Transcription By RNA Polymerase II
Response To Osmotic Stress
Ion Transmembrane Transport
Negative Regulation Of Activation-induced Cell Death Of T Cells
Follicular Dendritic Cell Differentiation
Germinal Center Formation
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Aging
Extracellular Matrix Organization
Positive Regulation Of Type I Interferon Production
Response To Lipopolysaccharide
Response To Cytokine
NIK/NF-kappaB Signaling
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Spleen Development
Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways
Stimuli-sensing channels
RIP-mediated NFkB activation via ZBP1
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
PKMTs methylate histone lysines
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Interleukin-1 processing
SUMOylation of immune response proteins
IkBA variant leads to EDA-ID
Dectin-1 mediated noncanonical NF-kB signaling
NIK-->noncanonical NF-kB signaling
The NLRP3 inflammasome
TRAF6 mediated NF-kB activation
Purinergic signaling in leishmaniasis infection
Drugs
Donepezil
Glucosamine
HE3286
P54
NOX-700
SGN-30
Custirsen
NF-kappaB Decoy
Andrographolide
Glycyrrhizic acid
Fish oil
SC-236
Diseases
GWAS
Metabolite levels (
23823483
)
Refractive error (
32231278
)
Ulcerative colitis (
26192919
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
14 interacting genes:
BRME1
DCLK2
FOS
HPCAL4
JUN
MAD1L1
MTA2
NFKB1
NFKB2
PLEKHF2
RAF1
REL
RELA
SUMO1
36 interacting genes:
BCL3
BTRC
CHUK
DDX3X
DPF2
EPS8
GLG1
GTF2I
HDAC4
HDAC5
IKBKB
IKBKG
MAP3K14
MAP3K8
MEN1
MTDH
NFKB1
NFKBIA
NFKBIB
NFKBIE
NFKBIZ
NKRF
NR3C1
NR5A1
PSMD11
REL
RELA
RELB
RPL30
RPL6
RPS13
SIN3A
SP1
TNIP2
TSC22D3
USP2
Entrez ID
1831
4791
HPRD ID
04266
01239
Ensembl ID
ENSG00000157514
ENSG00000077150
Uniprot IDs
Q5JRJ2
Q99576
Q00653
PDB IDs
1A3Q
2D96
3DO7
4OT9
5ZMC
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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