DRD4 and KCNJ9

Data Source:
HPRD (in vitro, in vivo)

		DRD4	KCNJ9
Description		dopamine receptor D4	potassium inwardly rectifying channel subfamily J member 9
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Dendrite Postsynapse Glutamatergic Synapse	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Dopamine Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Potassium Channel Regulator Activity SH3 Domain Binding Neurotransmitter Receptor Activity Dopamine Binding Identical Protein Binding Metal Ion Binding Epinephrine Binding Norepinephrine Binding	Inward Rectifier Potassium Channel Activity Protein Binding G-protein Activated Inward Rectifier Potassium Channel Activity
	Biological Process	Activation Of MAPK Activity Behavioral Fear Response Synaptic Transmission, Dopaminergic Response To Amphetamine Cellular Calcium Ion Homeostasis G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Chemical Synaptic Transmission Adult Locomotory Behavior Positive Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Kinase Activity Response To Histamine Social Behavior Regulation Of Dopamine Metabolic Process Dopamine Metabolic Process Fear Response Regulation Of Circadian Rhythm Behavioral Response To Cocaine Behavioral Response To Ethanol Rhythmic Process Arachidonic Acid Secretion Negative Regulation Of Protein Secretion Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Inhibitory Postsynaptic Potential G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Voltage-gated Calcium Channel Activity	Regulation Of Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways		Dopamine receptors G alpha (i) signalling events	Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs		Ziprasidone Cabergoline Ropinirole Olanzapine Clozapine Loxapine Remoxipride Pramipexole Chlorpromazine Buspirone Amoxapine Lisuride Apomorphine Dopamine Ergoloid mesylate Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Paliperidone Methotrimeprazine Flibanserin Iloperidone Rotigotine Asenapine Sumanirole Perospirone Pipamperone Epicriptine Pardoprunox Dihydroergocristine Aripiprazole lauroxil	Ethanol Isavuconazole
Diseases
GWAS			Alcohol consumption over the past year ( 29058377)
Interacting Genes		9 interacting genes: ADCY2 ADRB2 CLIC6 GABRA1 GNAI1 GRB2 KCNJ9 KLHL12 NCK1	6 interacting genes: ADRB2 DRD2 DRD4 KCNJ3 KCNJ6 TMEM201
Entrez ID		1815	3765
HPRD ID		00541	02959
Ensembl ID		ENSG00000069696	ENSG00000162728
Uniprot IDs		P21917	Q92806
PDB IDs		5WIU 5WIV
Enriched GO Terms of Interacting Partners?
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