DRD1 and PDCD6IP

Data Source:
BioGRID (two hybrid, pull down)

		DRD1	PDCD6IP
Description		dopamine receptor D1	programmed cell death 6 interacting protein
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cilium Dendritic Spine Ciliary Membrane Non-motile Cilium	Immunological Synapse Microtubule Organizing Center Cytosol Bicellular Tight Junction Focal Adhesion Membrane Melanosome Actomyosin Intracellular Membrane-bounded Organelle Extracellular Exosome Endoplasmic Reticulum Exit Site Flemming Body Extracellular Vesicle
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs G Protein-coupled Receptor Activity Dopamine Neurotransmitter Receptor Activity Protein Binding Dopamine Binding	Protein Binding Proteinase Activated Receptor Binding Protein Homodimerization Activity Calcium-dependent Protein Binding
	Biological Process	Synaptic Transmission, Dopaminergic G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Synapse Assembly Mating Behavior Adult Walking Behavior Visual Learning Positive Regulation Of Gene Expression Transmission Of Nerve Impulse Cerebral Cortex GABAergic Interneuron Migration Positive Regulation Of Cell Migration Vasodilation Dopamine Metabolic Process Response To Drug Positive Regulation Of Potassium Ion Transport Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Synaptic Transmission, Glutamatergic Prepulse Inhibition Phospholipase C-activating Dopamine Receptor Signaling Pathway Cellular Response To Catecholamine Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Cellular Response To Dopamine	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Apoptotic Process Nucleus Organization Mitotic Metaphase Plate Congression Regulation Of Centrosome Duplication Protein Transport Viral Life Cycle Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Maintenance Of Epithelial Cell Apical/basal Polarity Viral Budding Protein Homooligomerization Midbody Abscission Bicellular Tight Junction Assembly Regulation Of Membrane Permeability Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Assembly Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly Positive Regulation Of Extracellular Exosome Assembly
Pathways		Dopamine receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Budding and maturation of HIV virion Uptake and function of anthrax toxins RIPK1-mediated regulated necrosis Regulation of necroptotic cell death
Drugs		Ziprasidone Cabergoline Cabergoline Olanzapine Olanzapine Methylergometrine Clozapine Phenylpropanolamine Loxapine Loxapine Imipramine Chlorpromazine Chlorpromazine Haloperidol Triflupromazine Amoxapine Lamotrigine Cinnarizine Lisuride Fluphenazine Thioridazine Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Fenoldopam Minaprine Perphenazine Flupentixol Dopamine Dopamine Carphenazine Ergoloid mesylate Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Chlorprothixene Paliperidone Methotrimeprazine Periciazine Acepromazine Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Iloperidone Rotigotine Lumateperone Mianserin Asenapine Quinagolide Zotepine Pipamperone Dihydro-alpha-ergocryptine Epicriptine Pipradrol Tetrahydropalmatine Dihydrexidine Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Cadmium levels ( 26025379) Chin dimples ( 27182965) Falling risk ( 32999390) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Treatment response for severe sepsis ( 22310353) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Neuroticism ( 27089181) Periodontitis (Mean PAL) ( 24024966) Rosacea symptom severity ( 29771307) Severe influenza A (H1N1) infection ( 26379185) Smoking status (ever vs never smokers) ( 30643258) Visceral adipose tissue adjusted for BMI ( 22589738) White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure) ( 31044621)
Interacting Genes		16 interacting genes: ADA ADORA1 CALY CAV2 COPG1 COPG2 DNAJC14 DRD3 EPB41L2 FLNA GHSR GRIN1 HRH3 PDCD6IP PRKACA VPS35	36 interacting genes: ARRDC1 ARRDC3 ATN1 CD2AP CEP55 CHMP4A CHMP4B CHMP4C CXCR1 DRD1 EGFR F2R GRB2 ITSN1 ITSN2 KEAP1 MAPK6 PDCD6 PTK2B RAMP3 RNF11 SDCBP SH3GL1 SH3GL2 SH3GL3 SH3KBP1 SH3RF1 SRC SUMO2 TAB1 TSG101 TTF2 UBC VPS28 VPS37C YES1
Entrez ID		1812	10015
HPRD ID		00538	06425
Ensembl ID		ENSG00000184845	ENSG00000170248
Uniprot IDs		P21728	Q8WUM4
PDB IDs		1OZ5	2OEV 2OEW 2OEX 2OJQ 2R02 2R03 2R05 2XS1 2XS8 2ZNE 3C3O 3C3Q 3C3R 3E1R 3WUV 4JJY 5V3R 5WA1 6KP3
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?