DNM2 and AOC1

Data Source:
HPRD (in vivo, in vitro)

		DNM2	AOC1
Description		dynamin 2	amine oxidase copper containing 1
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GO Annotations	Cellular Component	Golgi Membrane Phagocytic Cup Nucleus Cytoplasm Endosome Golgi Apparatus Trans-Golgi Network Centrosome Cytosol Microtubule Plasma Membrane Clathrin-coated Pit Focal Adhesion Postsynaptic Density Microtubule Cytoskeleton Membrane Lamellipodium Axon Growth Cone Midbody Endocytic Vesicle Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Mitochondrial Membrane Ruffle Membrane Protein-containing Complex Dendritic Spine Head Postsynaptic Membrane Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Presynapse Postsynaptic Endocytic Zone Membrane Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Extracellular Region Extracellular Space Peroxisome Plasma Membrane Bicellular Tight Junction Specific Granule Lumen Extracellular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding Microtubule Binding SH3 Domain Binding Enzyme Binding Protein Kinase Binding D2 Dopamine Receptor Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Protein-containing Complex Binding WW Domain Binding Nitric-oxide Synthase Binding	Copper Ion Binding Calcium Ion Binding Protein Binding Primary Amine Oxidase Activity Heparin Binding Zinc Ion Binding Protein Homodimerization Activity Protein-containing Complex Binding Quinone Binding Diamine Oxidase Activity Histamine Oxidase Activity Methylputrescine Oxidase Activity Propane-1,3-diamine Oxidase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitochondrial Fission G Protein-coupled Receptor Internalization Dynamin Family Protein Polymerization Involved In Mitochondrial Fission Regulation Of Transcription, DNA-templated Golgi To Plasma Membrane Transport Endocytosis Receptor-mediated Endocytosis Phagocytosis Signal Transduction Spermatogenesis Response To Light Stimulus Positive Regulation Of Lamellipodium Assembly Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Axon Extension Receptor Internalization Transferrin Transport Regulation Of Rac Protein Signal Transduction Response To Cocaine Positive Regulation Of Apoptotic Process Macropinocytosis Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Synaptic Vesicle Transport Neuron Projection Morphogenesis Positive Regulation Of Phagocytosis Regulation Of Synapse Structure Or Activity Regulation Of Nitric-oxide Synthase Activity Membrane Organization Membrane Fusion Cellular Response To Carbon Monoxide Cellular Response To X-ray Cellular Response To Nitric Oxide Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Non-motile Cilium Assembly Cellular Response To Dopamine Regulation Of Golgi Organization Positive Regulation Of Sodium:potassium-exchanging ATPase Activity Negative Regulation Of Membrane Tubulation Positive Regulation Of Clathrin-dependent Endocytosis	Xenobiotic Metabolic Process Amine Metabolic Process Putrescine Metabolic Process Cellular Response To Copper Ion Starvation Neutrophil Degranulation Response To Antibiotic Cellular Response To Copper Ion Cellular Response To Histamine Cellular Response To Heparin Cellular Response To Azide
Pathways		Toll Like Receptor 4 (TLR4) Cascade Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions NOSTRIN mediated eNOS trafficking MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 Clathrin-mediated endocytosis NGF-stimulated transcription	Phase I - Functionalization of compounds Neutrophil degranulation
Drugs			Amiloride Calcium Diminazene
Diseases		Centronuclear myopathy Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Bipolar disorder ( 31043756) Height ( 25429064) Hyperlipidemia (time to event) ( 32589924) LDL cholesterol ( 21347282)	Anthropometric traits (multi-trait analysis) ( 30166351) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) Carpal tunnel syndrome ( 30833571) Eyebrow thickness ( 26926045) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Serum metabolite concentrations in chronic kidney disease ( 29545352) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Type 2 diabetes ( 30297969) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		68 interacting genes: AMPH AOC1 AP2A1 APP APPL1 ATF7IP ATXN3 BAG3 BIN1 CCDC90B CCR5 CCT7 CDK1 CTTN DDX39B DNM1 DYNC1I1 DYNLL1 EIF3L EPS15 FLAD1 FNBP1L GDF9 GOLGA2 GRAP2 GRB2 HCK HMGB1 ITSN1 KDR MAN1B1 MANEA MPHOSPH6 NTAQ1 PALS2 PDE6G PFN1 PPIB PRKAA2 PSTPIP1 PTK2 PYGM QARS1 RHOU RNF8 RPS2 RWDD2B SDCBP SEC23A SH3GL2 SH3GLB1 SH3RF1 SHANK1 SHANK2 SNAPIN SNX9 SPRY2 SRC TIAM2 TRAF4 TRIP10 TYK2 UBASH3A VAV1 WBP4 XIAP ZBTB16 ZFAND6	13 interacting genes: CYB561A3 DAO DAZAP2 DNM2 FGD1 FOXH1 KRTAP8-1 NTAQ1 POGZ RBPMS2 TIAL1 TLX3 ZC3H10
Entrez ID		1785	26
HPRD ID		03852	00088
Ensembl ID		ENSG00000079805	ENSG00000002726
Uniprot IDs		P50570 Q8N1K8	P19801
PDB IDs		2YS1	3HI7 3HIG 3HII 3K5T 3MPH
Enriched GO Terms of Interacting Partners?
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