DLST and ESRRB

Data Source:
BioGRID (proximity labelling technology)

		DLST	ESRRB
Description		dihydrolipoamide S-succinyltransferase	estrogen related receptor beta
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Membrane Centriolar Satellite Oxoglutarate Dehydrogenase Complex	Chromatin Condensed Chromosome Nucleus Nucleoplasm Cytoplasm Cytosol Integrator Complex
	Molecular Function	Dihydrolipoyllysine-residue Succinyltransferase Activity Protein Binding Transferase Activity, Transferring Acyl Groups	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Steroid Binding Transcription Factor Binding Zinc Ion Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Tricarboxylic Acid Cycle 2-oxoglutarate Metabolic Process Succinyl-CoA Metabolic Process Lysine Catabolic Process Protein Phosphopantetheinylation L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Histone Succinylation	Embryonic Placenta Development Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Stem Cell Division Stem Cell Population Maintenance Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Cell Dedifferentiation Photoreceptor Cell Maintenance Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Inner Ear Development Positive Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Transcription Involved In G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Division Negative Regulation Of Stem Cell Differentiation
Pathways		Glyoxylate metabolism and glycine degradation Lysine catabolism Citric acid cycle (TCA cycle)	Nuclear Receptor transcription pathway
Drugs			Diethylstilbestrol Genistein Flavone
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Depression ( 29700475) Eosinophil counts ( 32888494) Mood instability ( 29187730) Non-small cell lung cancer ( 23144319)	Maximal oxygen uptake response ( 25729143) Sphingomyelin 24:0 levels ( 31560688) Tuberculosis ( 30287856)
Interacting Genes		16 interacting genes: ARIH2 CCDC86 DLG5 FLII NAP1L1 NDRG1 OGDH PAK4 PFN2 RUSC2 SCFD1 TUBB4B UBE2D2 UMPS ZBTB16 ZHX1	8 interacting genes: ESRRG HIF1A HSP90AA1 HSP90AB1 NCOA2 NCOA3 NRIP1 SP1
Entrez ID		1743	2103
HPRD ID		00520	03700
Ensembl ID		ENSG00000119689	ENSG00000119715
Uniprot IDs		A0A024R6C9 B7Z6J1 P36957	O95718
PDB IDs		6H05	1LO1 6LIT 6LN4
Enriched GO Terms of Interacting Partners?
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