PSORS1C2 and EVPL

Data Source:
HPRD (in vivo)

		PSORS1C2	EVPL
Description		psoriasis susceptibility 1 candidate 2	envoplakin
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Extracellular Region	Cornified Envelope Cytoplasm Cytosol Intermediate Filament Membrane Desmosome Intermediate Filament Cytoskeleton Extracellular Exosome
	Molecular Function	Molecular_function Protein Binding	Structural Molecule Activity Intermediate Filament Binding Cadherin Binding
	Biological Process	Biological_process	Epidermis Development Peptide Cross-linking Keratinocyte Differentiation Wound Healing Intermediate Filament Cytoskeleton Organization Cornification
Pathways			Formation of the cornified envelope
Drugs
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Broad depression or schizophrenia ( 30626913) Height ( 28552196 25282103) Hematology traits ( 23263863) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Metabolite levels ( 23823483) Multiple myeloma ( 26007630) Multiple myeloma and monoclonal gammopathy ( 26007630) Night sleep phenotypes ( 27126917) Serum uric acid levels ( 30993211) Ulcerative colitis ( 28067908) White blood cell count ( 21738480)	Deep white matter hyperintensities ( 32517579) Depressive symptom improvement ( 30468137) L-selectin levels ( 25576479) Metabolite levels ( 23823483) Periventricular white matter hyperintensities ( 32517579)
Interacting Genes		27 interacting genes: AGR2 AP1B1 AP2B1 BANP CEP70 ERICH2 EVPL GUCA1C HMG20A HOMER3 LHX3 MED20 MEIS3 MYL2 MYL7 NCKIPSD PAX6 PEX19 REL RTRAF SERTAD1 SGTA SGTB TTC23 UBQLN1 UBQLN2 VASP	14 interacting genes: CSTA DSP IVL KRT1 KRT10 KRT2 KRT5 LORICRIN PI3 PLEKHA5 PPL PSORS1C2 SPRR2A SPRR3
Entrez ID		170680	2125
HPRD ID		17921	03352
Ensembl ID		ENSG00000204538	ENSG00000167880
Uniprot IDs		A0A1U9X9A6 Q9UIG4	B7ZLH8 K7EKI0 Q92817
PDB IDs			4QMD
Enriched GO Terms of Interacting Partners?
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