GSDME and GP1BB

Data Source:
BioGRID (affinity chromatography technology)

		GSDME	GP1BB
Description		gasdermin E	glycoprotein Ib platelet subunit beta
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Cardiolipin Binding	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Sensory Perception Of Sound Cell Death Negative Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Inner Ear Receptor Cell Differentiation Necrotic Cell Death Pyroptosis Cellular Response To Tumor Necrosis Factor Cellular Response To Virus Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Cell Adhesion Cell Surface Receptor Signaling Pathway Blood Coagulation Blood Coagulation, Intrinsic Pathway Platelet Activation
Pathways			Intrinsic Pathway of Fibrin Clot Formation GP1b-IX-V activation signalling Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) Defective F9 activation
Drugs
Diseases		Deafness, autosomal dominant	Bernard-Soulier syndrome; Giant platelet syndrome
GWAS			DNA methylation (parent-of-origin) ( 23725790) Mean platelet volume ( 32888494 27863252) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252)
Interacting Genes		3 interacting genes: ITGB1BP1 PTN TIFA	4 interacting genes: GP9 PRKACA TGFB1I1 YWHAZ
Entrez ID		1687	2812
HPRD ID		02996	00729
Ensembl ID		ENSG00000105928	ENSG00000203618
Uniprot IDs		A0A024RA58 A4FVA8 O60443	P13224
PDB IDs			3REZ 3RFE
Enriched GO Terms of Interacting Partners?
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