DES and B4GALT2

Data Source:
BioGRID (affinity chromatography technology)

		DES	B4GALT2
Description		desmin	beta-1,4-galactosyltransferase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Intermediate Filament Fascia Adherens Intercalated Disc Z Disc Neuromuscular Junction Sarcolemma Intermediate Filament Cytoskeleton Extracellular Exosome Cardiac Myofibril	Golgi Membrane Nucleoplasm Golgi Apparatus Integral Component Of Membrane Golgi Cisterna Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Identical Protein Binding	Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity N-acetyllactosamine Synthase Activity Lactose Synthase Activity Galactosyltransferase Activity Metal Ion Binding
	Biological Process	Muscle Contraction Cytoskeleton Organization Regulation Of Heart Contraction Muscle Filament Sliding Intermediate Filament Organization	Carbohydrate Metabolic Process Protein Glycosylation Memory Locomotory Behavior Visual Learning Keratan Sulfate Biosynthetic Process Cerebellar Purkinje Cell Layer Development Glycosylation
Pathways		Striated Muscle Contraction	Keratan sulfate biosynthesis N-Glycan antennae elongation
Drugs
Diseases		Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Scapuloperoneal myopathy (SPM) Dilated cardiomyopathy (DCM)
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Resting heart rate ( 27798624)	Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576 29875488)
Interacting Genes		60 interacting genes: AURKB BAG5 BRCA1 C1orf216 CAPN1 CLIP4 CRYAB CT55 CWF19L2 DDX6 DSP DUX1 DUX4 EHHADH ENO1 GFAP GOLGA6L9 HSPB1 ITSN1 KRT13 KRT15 KRT20 KRT33B KRT37 KRT75 LBX1 LENG1 LMO4 LONRF3 M1AP MAPKAPK2 NEB NEFL NEK6 PIAS2 PIH1D2 PKD1 PLEKHA5 POLR2G PPL PPP1R18 PRPH RNF4 ROCK1 S100A1 S100B SHBG SNAPIN SPTAN1 SYNC SYNM TCEA2 TFIP11 TRIM55 TRIM63 TRIM7 UBE2I VIM YES1 ZMYM5	3 interacting genes: GPR35 MEOX2 PFDN6
Entrez ID		1674	8704
HPRD ID		00514	04928
Ensembl ID		ENSG00000175084	ENSG00000117411
Uniprot IDs		P17661 Q53SB5	O60909
PDB IDs
Enriched GO Terms of Interacting Partners?
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