DCP2 and FEM1C

Data Source:
HPRD (in vitro)

		DCP2	FEM1C
Description		decapping mRNA 2	fem-1 homolog C
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GO Annotations	Cellular Component	P-body Nucleoplasm Cytoplasm Cytosol RISC Complex Cell Junction Cytoplasmic Ribonucleoprotein Granule	Ubiquitin Ligase Complex Nucleoplasm Cytosol
	Molecular Function	5'-3' Exoribonuclease Activity Protein Binding Exoribonuclease Activity, Producing 5'-phosphomonoesters Manganese Ion Binding M7G(5')pppN Diphosphatase Activity Telomerase RNA Binding	Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MRNA Catabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA Histone MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Regulation Of Telomerase RNA Localization To Cajal Body	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Post-translational Protein Modification
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA	Neddylation
Drugs
Diseases
GWAS		Worry/vulnerability (special factor of neuroticism) ( 30867560)	Conotruncal heart defects (inherited effects) ( 28468790) Response to antidepressants (symptom improvement) ( 29160301)
Interacting Genes		12 interacting genes: AGO1 AGO2 DCP1A DCP1B MIR15B MTOR NAGK POLA2 PSMB1 TRIM21 UPF1 UPF2	7 interacting genes: BCL2L11 CEP63 LZTS2 MALT1 MCM8 PNMA1 RPGRIP1
Entrez ID		167227	56929
HPRD ID		13125	16384
Ensembl ID		ENSG00000172795	ENSG00000145780
Uniprot IDs		Q8IU60	Q96JP0
PDB IDs		5MP0 5QOH 5QOI 5QOJ 5QOK 5QOL 5QOM 5QON 5QOO 5QOP 5QOQ 5QOR 5QOS 5QOT 5QOU 5QOV 5QOW 5QOX 5QOY 5QOZ 5QP0 5QP1 5QP2 5QP3 5QP4 5QP5 5QP6 5QP7 5QP8 5QP9 5QPA 5QPB 5QPC	6LBG 6LBN 6LDP 6LE6 6LEN 6LEY 6LF0 6XKC 7JYA
Enriched GO Terms of Interacting Partners?
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