DCP2 and KCNN2

Data Source:
BioGRID (proximity labelling technology)

		DCP2	KCNN2
Description		decapping mRNA 2	potassium calcium-activated channel subfamily N member 2
Image
GO Annotations	Cellular Component	P-body Nucleoplasm Cytoplasm Cytosol RISC Complex Cell Junction Cytoplasmic Ribonucleoprotein Granule	Plasma Membrane Cell Surface Integral Component Of Membrane Z Disc Neuron Projection Neuronal Cell Body Dendritic Spine
	Molecular Function	5'-3' Exoribonuclease Activity Protein Binding Exoribonuclease Activity, Producing 5'-phosphomonoesters Manganese Ion Binding M7G(5')pppN Diphosphatase Activity Telomerase RNA Binding	Protein Binding Calmodulin Binding Calcium-activated Potassium Channel Activity Small Conductance Calcium-activated Potassium Channel Activity Protein Domain Specific Binding Protein Homodimerization Activity Alpha-actinin Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MRNA Catabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA Histone MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Regulation Of Telomerase RNA Localization To Cajal Body	Ion Transport Potassium Ion Transport Potassium Ion Transmembrane Transport Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA	Ca2+ activated K+ channels
Drugs			Procaine Miconazole Trimebutine
Diseases
GWAS		Worry/vulnerability (special factor of neuroticism) ( 30867560)	Alzheimer disease and age of onset ( 26830138) Atrial fibrillation ( 28416818 30061737 29892015) Coronary arterial lesions in patients with Kawasaki disease ( 23677057) Diastolic blood pressure ( 27841878) Generalized epilepsy ( 30531953) JT interval (sulfonylurea treatment interaction) ( 27958378) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Systolic blood pressure ( 27841878)
Interacting Genes		12 interacting genes: AGO1 AGO2 DCP1A DCP1B MIR15B MTOR NAGK POLA2 PSMB1 TRIM21 UPF1 UPF2	4 interacting genes: ACTN2 CALM1 SRPK1 SRPK2
Entrez ID		167227	3781
HPRD ID		13125	09323
Ensembl ID		ENSG00000172795	ENSG00000080709
Uniprot IDs		Q8IU60	A0A3F2YNY5 Q9H2S1
PDB IDs		5MP0 5QOH 5QOI 5QOJ 5QOK 5QOL 5QOM 5QON 5QOO 5QOP 5QOQ 5QOR 5QOS 5QOT 5QOU 5QOV 5QOW 5QOX 5QOY 5QOZ 5QP0 5QP1 5QP2 5QP3 5QP4 5QP5 5QP6 5QP7 5QP8 5QP9 5QPA 5QPB 5QPC	5V02 5WBX 5WC5 6ALE
Enriched GO Terms of Interacting Partners?
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