DEFA1 and C1QB

Data Source:
HPRD (in vitro)

		DEFA1	C1QB
Description		defensin alpha 1	complement C1q B chain
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Azurophil Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Collagen Trimer Complement Component C1 Complex Synapse Collagen-containing Extracellular Matrix Blood Microparticle Postsynapse
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Innate Immune Response In Mucosa Chemotaxis Immune Response T Cell Chemotaxis Antimicrobial Humoral Response Antibacterial Humoral Response Intracellular Estrogen Receptor Signaling Pathway Killing Of Cells Of Other Organism Defense Response To Protozoan Neutrophil Degranulation Pore Formation In Membrane Of Other Organism During Symbiotic Interaction Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Defense Response To Virus Membrane Disruption In Other Organism Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide	Complement Activation Complement Activation, Classical Pathway Regulation Of Complement Activation Innate Immune Response Synapse Pruning
Pathways		Defensins Alpha-defensins Neutrophil degranulation	Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade
Drugs			Cetuximab Etanercept Palivizumab Daclizumab Bevacizumab Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Chromium levels ( 26025379) Dental caries (decayed and filled deciduous teeth) ( 31533690) Endometriosis ( 28333195) Periodontitis (PAL4Q3) ( 24024966)
Interacting Genes		6 interacting genes: C1QB DEFA3 GSK3B PFDN1 SERPINF2 UBQLN2	11 interacting genes: C1QA C1QC C1R DEFA1 EDA2R HRG IL32 MYOC PTX3 RELA UBQLN2
Entrez ID		1667	713
HPRD ID		00499	00394
Ensembl ID		ENSG00000206047	ENSG00000173369
Uniprot IDs		P59665	A0A024RAB9 P02746
PDB IDs		2KHT 2PM1 3GNY 3H6C 3HJ2 3HJD 3LO1 3LO2 3LO4 3LO6 3LO9 3LOE 3LVX 4DU0 4LB1 4LB7 4LBB 4LBF	1PK6 2JG8 2JG9 2WNU 2WNV 5HKJ 5HZF 6FCZ 6Z6V
Enriched GO Terms of Interacting Partners?
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