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AP1B1 and PSME1
Data Source:
BioGRID
(affinity chromatography technology)
AP1B1
PSME1
Description
adaptor related protein complex 1 subunit beta 1
proteasome activator subunit 1
Image
GO Annotations
Cellular Component
Golgi Membrane
Lysosomal Membrane
Golgi Apparatus
Cytosol
Clathrin Adaptor Complex
Cytoplasmic Vesicle Membrane
Clathrin-coated Vesicle Membrane
Trans-Golgi Network Membrane
Intracellular Membrane-bounded Organelle
Proteasome Complex
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Activator Complex
Extracellular Exosome
Molecular Function
Protein Binding
Protein Kinase Binding
Clathrin Binding
Protein Binding
Endopeptidase Activator Activity
Biological Process
Kidney Development
Intracellular Protein Transport
Determination Of Left/right Symmetry
Heart Development
Vesicle-mediated Transport
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Regulation Of Defense Response To Virus By Virus
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Regulation Of Cellular Amino Acid Metabolic Process
Positive Regulation Of Endopeptidase Activity
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of MRNA Stability
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Nef mediated downregulation of MHC class I complex cell surface expression
MHC class II antigen presentation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Copper
Diseases
GWAS
Carotid atherosclerosis in HIV infection (
20009918
)
Heel bone mineral density (
30598549
28869591
)
High light scatter reticulocyte count (
32888494
27863252
)
High light scatter reticulocyte percentage of red cells (
32888494
27863252
)
Immature fraction of reticulocytes (
32888494
27863252
)
Pancreatic cancer (
25086665
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Interacting Genes
43 interacting genes:
AGR3
AP1G1
AP1G2
AP1M2
ARF1
ARF5
ARF6
ARRB2
ATF7IP
ATM
ATR
BARD1
BUB1
BUB1B
CLTC
CREBBP
CRYBB1
FARS2
FMNL2
FNDC11
GPANK1
GTF2I
KIF13A
LDLRAP1
MLH1
MSGN1
MTNR1B
MYG1
NECAP1
NTRK2
NUP54
PIP5K1C
POM121
PRKDC
PSORS1C2
RNF39
SHBG
SLC2A8
SMAD2
TBC1D22B
TSGA10IP
U2AF1
U2AF1L5
19 interacting genes:
AIMP2
APP
ATP1B1
CDC37
CHD3
EIF6
EMD
EMG1
PFDN1
PIK3R3
PSME2
RPP14
SETDB1
SMN1
TK1
TUBB4B
USP22
VCL
VIM
Entrez ID
162
5720
HPRD ID
02541
02803
Ensembl ID
ENSG00000100280
ENSG00000092010
Uniprot IDs
Q10567
A0A0K0K1L8
Q06323
Q86SZ9
PDB IDs
4HMY
4P6Z
6CM9
6CRI
6D83
6D84
6DFF
1AVO
Enriched GO Terms of Interacting Partners
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