AP2A2 and DNAJC6

Data Source:
HPRD (in vitro)

		AP2A2	DNAJC6
Description		adaptor related protein complex 2 subunit alpha 2	DnaJ heat shock protein family (Hsp40) member C6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane AP-2 Adaptor Complex Endocytic Vesicle Membrane Secretory Granule Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Clathrin-coated Endocytic Vesicle Ficolin-1-rich Granule Membrane	Cytoplasm Cytosol Postsynaptic Density Vesicle Intracellular Membrane-bounded Organelle Presynapse
	Molecular Function	Molecular_function Protein Binding Lipid Binding Protein Kinase Binding Clathrin Adaptor Activity Disordered Domain Specific Binding Cargo Adaptor Activity	Protein Tyrosine Phosphatase Activity SH3 Domain Binding Clathrin Binding
	Biological Process	Intracellular Protein Transport Receptor-mediated Endocytosis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Low-density Lipoprotein Particle Receptor Catabolic Process Low-density Lipoprotein Particle Clearance Neutrophil Degranulation Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Organization Clathrin-dependent Endocytosis	Synaptic Vesicle Uncoating Peptidyl-tyrosine Dephosphorylation Membrane Organization Clathrin Coat Disassembly Clathrin-dependent Endocytosis Regulation Of Clathrin-dependent Endocytosis
Pathways		Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Neutrophil degranulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS	Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Adult asthma ( 27611488) Alzheimer's disease ( 30636644) Alzheimer's disease (late onset) ( 24162737) Asthma ( 31959851) Chronic bronchitis and chronic obstructive pulmonary disease ( 25241909) Nicotine withdrawal ( 29532581) Nicotine withdrawal symptom count ( 29532581)	Anticoagulant levels ( 22216198) Idiopathic osteonecrosis of the femoral head ( 28000841)
Interacting Genes		18 interacting genes: AAGAB AMPH AP1S1 AP2B1 APP BIN1 DNAJC6 DNM1 EPN1 EPS15 HTT NLGN3 NUMB SHC1 SLC2A8 SMAD1 SNAP91 UBC	3 interacting genes: AP2A2 BAG2 CLTC
Entrez ID		161	9829
HPRD ID		06256	16326
Ensembl ID		ENSG00000183020	ENSG00000116675
Uniprot IDs		O94973	O75061
PDB IDs
Enriched GO Terms of Interacting Partners?
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