CYP17A1 and BARX1

Data Source:
BioGRID (two hybrid)

		CYP17A1	BARX1
Description		cytochrome P450 family 17 subfamily A member 1	BARX homeobox 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane	Chromatin Nucleus
	Molecular Function	Steroid 17-alpha-monooxygenase Activity Iron Ion Binding Oxygen Binding Heme Binding 17-alpha-hydroxyprogesterone Aldolase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity
	Biological Process	Steroid Biosynthetic Process Androgen Biosynthetic Process Glucocorticoid Biosynthetic Process Sex Differentiation Steroid Metabolic Process Hormone Biosynthetic Process Progesterone Metabolic Process	Regulation Of Transcription By RNA Polymerase II Cell-cell Signaling Anterior/posterior Pattern Specification Negative Regulation Of Wnt Signaling Pathway Epithelial Cell Differentiation Spleen Development Digestive System Development
Pathways		Androgen biosynthesis Glucocorticoid biosynthesis Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
Drugs		NADH Progesterone Spironolactone Ketoconazole Abiraterone Cannabidiol Medical Cannabis Nabiximols
Diseases		46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS) Congenital adrenal hyperplasia (CAH)
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Birth weight ( 31043758) Blood pressure ( 21572416 24001895 21909110) Brain morphology (MOSTest) ( 32665545) Colorectal cancer ( 26965516) Coronary artery disease ( 32469254 24262325 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Diastolic blood pressure ( 27841878 28739976 27618452 25249183) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Hip circumference ( 25673412) Hypertension ( 31879980 25249183 30487518) Mean arterial pressure ( 26390057 27618448 30487518) Microalbuminuria ( 26631737) Myocardial infarction ( 26343387) Parkinson's disease ( 19915575) Prostate cancer ( 23535732) Pulse pressure ( 27841878 28739976 30487518) Schizophrenia ( 25056061 29483656 23974872) Sodium levels ( 29403010) Systolic blood pressure ( 26390057 27736895 28135244 19430479 19430483 27841878 21909115 28739976 27618447 27618452 25249183 30487518) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Waist circumference ( 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Barrett's esophagus ( 24121790) Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined) ( 24121790) Esophageal adenocarcinoma ( 24121790) Heel bone mineral density ( 28869591) Parkinson's disease ( 26227905) Serum folate levels ( 29953918)
Interacting Genes		15 interacting genes: APC ATP5F1E BARX1 CDO1 CHEK2 CYB5A ERBB2 FZR1 HSP90AB1 IGF1R POR PTPRJ RPAIN STK11 TIGD7	5 interacting genes: CYP17A1 HOXD9 MAPK6 RPS6KA3 UBC
Entrez ID		1586	56033
HPRD ID		01944	16017
Ensembl ID		ENSG00000148795	ENSG00000131668
Uniprot IDs		P05093 Q1HB44	Q9HBU1
PDB IDs		2C17 3RUK 3SWZ 4NKV 4NKW 4NKX 4NKY 4NKZ 5IRQ 5IRV 5UYS 6CHI 6CIR 6CIZ	2DMT
Enriched GO Terms of Interacting Partners?
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