CYP2C18 and KMT2E

Data Source:
BioGRID (proximity labelling technology)

		CYP2C18	KMT2E
Description		cytochrome P450 family 2 subfamily C member 18	lysine methyltransferase 2E (inactive)
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle	Chromatin Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Plasma Membrane Nuclear Body Nuclear Speck Protein-containing Complex Transcriptionally Active Chromatin
	Molecular Function	Monooxygenase Activity Iron Ion Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Retinoic Acid 4-hydroxylase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Heme Binding Aromatase Activity	Protein Binding Histone-lysine N-methyltransferase Activity Enzyme Binding Methylated Histone Binding Metal Ion Binding
	Biological Process	Organic Acid Metabolic Process Xenobiotic Metabolic Process Epoxygenase P450 Pathway Retinoic Acid Metabolic Process Exogenous Drug Catabolic Process	Neutrophil Mediated Immunity DNA Methylation Cell Cycle Arrest Erythrocyte Differentiation Histone Lysine Methylation Neutrophil Activation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Histone H3-K4 Trimethylation
Pathways		Xenobiotics	PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs		N,4-Dimethyl-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide
Diseases
GWAS		Acenocoumarol maintenance dosage ( 19578179) Clopidogrel active metabolite levels ( 28207573) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Red cell distribution width ( 32888494) Response to clopidogrel therapy ( 28207573 19706858) Serum metabolite levels ( 23093944) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Warfarin maintenance dose ( 23755828) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)	Advanced age-related macular degeneration ( 26691988) Autism spectrum disorder ( 30804558) Autism spectrum disorder or schizophrenia ( 28540026) General risk tolerance (MTAG) ( 30643258) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neutrophil count ( 32888494) Schizophrenia ( 29483656)
Interacting Genes		5 interacting genes: A2M APOE ECSIT PSEN1 SDC2	4 interacting genes: ASH2L ATP13A1 CDK1 LAMTOR5
Entrez ID		1562	55904
HPRD ID		03085	10528
Ensembl ID		ENSG00000108242	ENSG00000005483
Uniprot IDs		P33260 Q7Z348	Q8IZD2
PDB IDs		2CIK 2H6P	2LV9 4L58 5HT6
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?