RASGEF1B and PDLIM7

Data Source:
BioGRID (two hybrid)

		RASGEF1B	PDLIM7
Description		RasGEF domain family member 1B	PDZ and LIM domain 7
Image		No pdb structure
GO Annotations	Cellular Component	Early Endosome Late Endosome Midbody	Stress Fiber Ruffle Nucleoplasm Cytosol Adherens Junction Focal Adhesion Actin Cytoskeleton Z Disc Filamentous Actin
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity	Actin Binding Protein Binding Metal Ion Binding Muscle Alpha-actinin Binding
	Biological Process	Small GTPase Mediated Signal Transduction Regulation Of Catalytic Activity	Ossification Receptor-mediated Endocytosis Axon Guidance Heart Development Actin Cytoskeleton Organization Positive Regulation Of Osteoblast Differentiation Muscle Structure Development
Pathways			RET signaling
Drugs
Diseases
GWAS		Body mass index ( 28552196) Cocaine dependence ( 31212010) Coronary artery disease ( 32469254 33020668) Depression in smokers ( 30219690) Diffusing capacity of carbon monoxide ( 30694715) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Height ( 25429064 31562340 18391951) Major depressive disorder ( 23377640) Plasma parathyroid hormone levels ( 30134803) Pursuit maintenance gain ( 29064472) Refractive error ( 32231278) Response to antidepressants in depression ( 29998114) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Waist circumference ( 28552196) White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure) ( 31044621)	Coronary artery disease ( 29212778) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		4 interacting genes: BAZ2B PDLIM7 PLEKHF2 TSGA10IP	62 interacting genes: ABI2 AP5B1 BAG3 BSG CATSPER1 CCDC185 DDX6 DGCR6 DNER ENKD1 FAM214B FAM71C FAM90A1 FNDC11 FRS3 GEM GFAP GPATCH2L HEY2 HNRNPD HNRNPF HSF2BP HSPB7 IL16 IQGAP1 KANK2 MDM2 NUDT10 OTUD6A PAK5 PARVG PCBP1 PHF1 PIN1 PLEKHN1 PRKCA PRKCB PRKCZ PRKD2 PSMF1 RASGEF1B RET RPP25 SCNM1 SH2B2 SH3BP2 SLAIN1 SMURF1 SPP1 TCF19 TNPO2 TP53 TPM2 TRAF2 TRAF3 TSG101 TSGA10IP UBE2I UBQLN4 WWP2 ZMYND11 ZNF165
Entrez ID		153020	9260
HPRD ID		17955	10436
Ensembl ID		ENSG00000138670	ENSG00000196923
Uniprot IDs		Q0VAM2	Q9NR12
PDB IDs			2Q3G
Enriched GO Terms of Interacting Partners?
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