CUX1 and CDC25A

Data Source:
HPRD (in vivo, in vitro)

		CUX1	CDC25A
Description		cut like homeobox 1	cell division cycle 25A
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nucleoplasm Golgi Apparatus Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein-macromolecule Adaptor Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding Chaperone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Retrograde Transport, Vesicle Recycling Within Golgi Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Positive Regulation Of Dendrite Morphogenesis	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Cell Population Proliferation Response To Radiation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Deubiquitination Cellular Response To UV Peptidyl-tyrosine Dephosphorylation Cell Division Regulation Of Cell Cycle Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle
Pathways		Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Intra-Golgi traffic	Transcription of E2F targets under negative control by DREAM complex Polo-like kinase mediated events Activation of ATR in response to replication stress Ub-specific processing proteases Cyclin E associated events during G1/S transition Cyclin A/B1/B2 associated events during G2/M transition Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Cyclin A:Cdk2-associated events at S phase entry Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder symptom score ( 27663945) Basal cell carcinoma ( 31174203 27539887) Breast cancer ( 29059683) Cerebellum cortex volume ( 31530798) Chronotype ( 30696823) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence (MTAG) ( 29326435) Keratinocyte cancer (MTAG) ( 31174203) Mean platelet volume ( 32888494 27863252) Morning person ( 30696823) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Response to antidepressants ( 22584459) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Blood protein levels ( 28240269) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 27841878) HDL cholesterol levels ( 32203549) Household income (MTAG) ( 31844048) Loneliness (multivariate analysis) ( 27629369) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (diuretics) ( 31015401) Pulse pressure ( 27841878) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878 27618447)
Interacting Genes		21 interacting genes: BIN1 CA12 CCNA1 CDC25A CDK1 CDK7 CREBBP CTSL CYTH2 EHMT2 ELAC2 GOLGA5 HMGB1 KAT2B MAX RB1 RECQL5 SATB1 SDC3 SUMO2 TLE4	56 interacting genes: APP AR BTRC CAMK1D CCNA1 CCNB1 CCNE1 CCNI CDK1 CDK2 CDK5 CDKN3 CHEK1 CHEK2 CSNK1A1 CUL3 CUX1 DMD DUSP8 EEF1A1 EGFR FAM193B FBXW11 FGF21 FTH1 FZR1 HDAC11 HLA-C HRAS IL3RA LMO2 MAP3K5 MAPK14 MCM3AP MTAP NAA10 NAA11 NFKBIB NFYA PEX19 PIM1 PKM POLR1D RAF1 ROCK1 SCYL1 SMAD3 SOX5 SRC UBB VAMP8 XPO1 YWHAB YWHAE YWHAQ YWHAZ
Entrez ID		1523	993
HPRD ID		00295	00305
Ensembl ID		ENSG00000257923	ENSG00000164045
Uniprot IDs		P39880 Q13948 Q3LIA3	A0A024R2R6 D8KXX0 K7N7S0 P30304
PDB IDs			1C25
Enriched GO Terms of Interacting Partners?
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