CTSV and MLH3

Data Source:
BioGRID (two hybrid)

		CTSV	MLH3
Description		cathepsin V	mutL homolog 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Lysosomal Lumen	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Mismatch Repair Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity	Chromatin Binding Satellite DNA Binding Protein Binding ATP Binding ATPase Activity Centromeric DNA Binding Mismatched DNA Binding
	Biological Process	Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Extracellular Matrix Disassembly Regulation Of Keratinocyte Differentiation Proteolysis Involved In Cellular Protein Catabolic Process	Mismatch Repair Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiosis I Protein Localization
Pathways		Endosomal/Vacuolar pathway Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures MHC class II antigen presentation RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	Meiotic recombination
Drugs		3-amino-5-phenylpentane 4-Methylpiperazin-1-Yl Carbonyl Group
Diseases			Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS			Inflammatory bowel disease ( 23128233) Mood instability ( 29187730) Refractive error ( 32231278)
Interacting Genes		13 interacting genes: APC BMPR1A BRAF BUB1 CDKN2A CTNNA1 DCC DLC1 MLH1 MLH3 PDGFRL RB1 SRC	45 interacting genes: AKT1 ALDOB ANP32B AOPEP AR BAAT CCDC180 CDC14B CDK8 CTSV CYLC2 DVL1 FANCC FBP1 FBP2 FRAT2 GALNT12 HEMGN HRAS HSD17B3 IGFBP3 LEF1 MAP2K1 MLH1 MSANTD3 MSH4 NANS PPP2CB PPP3R2 RASA1 SEC61B SFRP2 SMAD1 STX17 TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRIM55 TRIM63 TSTD2 XPA ZDHHC17 ZNF510
Entrez ID		1515	27030
HPRD ID		04495	05094
Ensembl ID		ENSG00000136943	ENSG00000119684
Uniprot IDs		A0A024R141 B2R717 O60911	Q2M1Z1 Q9UHC1
PDB IDs		1FH0 3H6S 3KFQ
Enriched GO Terms of Interacting Partners?
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