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SGO2 and PPP2R1B
Data Source:
HPRD
(two hybrid)
SGO2
PPP2R1B
Description
shugoshin 2
protein phosphatase 2 scaffold subunit Abeta
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Chromosome, Centromeric Region
Kinetochore
Condensed Chromosome Kinetochore
Nucleoplasm
Cytosol
Nuclear Body
Mitotic Cohesin Complex
Protein Phosphatase Type 2A Complex
Cytoplasm
Protein Serine/threonine Phosphatase Complex
Membrane Raft
Extracellular Exosome
Molecular Function
Protein Binding
Protein Serine/threonine Phosphatase Activity
Protein Binding
Protein Phosphatase Regulator Activity
Biological Process
Mitotic Sister Chromatid Segregation
Homologous Chromosome Segregation
Meiotic Sister Chromatid Cohesion
Cell Division
Meiotic Sister Chromatid Cohesion, Centromeric
Protein Dephosphorylation
Regulation Of Phosphoprotein Phosphatase Activity
Apoptotic Process Involved In Morphogenesis
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Integration of energy metabolism
PP2A-mediated dephosphorylation of key metabolic factors
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
MASTL Facilitates Mitotic Progression
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
CTLA4 inhibitory signaling
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS
Allergic disease (asthma, hay fever or eczema) (
29785011
)
Asthma (
31619474
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Brain morphology (MOSTest) (
32665545
)
Fish- and plant-related diet (
32066663
)
HDL cholesterol levels (
32203549
)
Mean spheric corpuscular volume (
32888494
)
Oily fish consumption (
32066663
)
Pork consumption (
32066663
)
Red blood cell count (
32888494
)
Interacting Genes
6 interacting genes:
CDCA8
PPP2CA
PPP2R1A
PPP2R1B
SET
SLAIN2
40 interacting genes:
AKAP9
ANXA5
BHLHE41
BSG
CDK1
CDK4
CEP43
CFTR
CLOCK
CRY1
CRY2
CSNK2B
DELEC1
EEF2
FBXW11
HDAC1
HSPD1
JAK2
MCM3
PARK7
PPP2CA
PPP2R2A
PPP2R3B
PPP2R5C
PPP2R5D
PPP2R5E
PRDX1
PRDX2
RAB11A
RAB18
RAB7A
RALA
RELA
RORC
SET
SGO1
SGO2
STRN
STRN3
UNC5B
Entrez ID
151246
5519
HPRD ID
11555
04384
Ensembl ID
ENSG00000163535
ENSG00000137713
Uniprot IDs
B7Z7S9
Q562F6
P30154
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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