CTLA4 and AOX1

Data Source:
HPRD (in vitro)

		CTLA4	AOX1
Description		cytotoxic T-lymphocyte associated protein 4	aldehyde oxidase 1
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GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Protein Complex Involved In Cell Adhesion	Cytosol Extracellular Exosome
	Molecular Function	Protein Binding	Aldehyde Oxidase Activity Iron Ion Binding Electron Transfer Activity Oxidoreductase Activity Identical Protein Binding Protein Homodimerization Activity Molybdopterin Cofactor Binding Flavin Adenine Dinucleotide Binding NAD Binding 2 Iron, 2 Sulfur Cluster Binding FAD Binding Geranial:oxygen Oxidoreductase Activity Heptaldehyde:oxygen Oxidoreductase Activity
	Biological Process	Adaptive Immune Response Immune Response Cellular Response To DNA Damage Stimulus Negative Regulation Of B Cell Proliferation T Cell Costimulation Negative Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Immune Response T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway	Drug Metabolic Process Electron Transport Chain Vitamin B6 Metabolic Process
Pathways		CTLA4 inhibitory signaling RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	Vitamins B6 activation to pyridoxal phosphate
Drugs		Ipilimumab Tremelimumab	Cyclobenzaprine Eniluracil
Diseases		Type I diabetes mellitus Graves' disease Allograft rejection Hashimoto's thyroiditis	Xanthinuria
GWAS		Alopecia areata ( 20596022 25608926) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 31174203) Celiac disease ( 22057235 20190752 25920553 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Graves' disease ( 21841780) Heel bone mineral density ( 30598549) Hypothyroidism ( 27182965 22493691) Inflammatory bowel disease ( 26192919) Keratinocyte cancer (MTAG) ( 31174203) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 24076602) Myasthenia gravis ( 25643325) Primary biliary cholangitis ( 28425483) Rheumatoid arthritis ( 30423114 30572963 23143596 24390342 20453842 19503088) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Subcutaneous adipose tissue ( 29178545) Systemic lupus erythematosus ( 33536424) Type 1 diabetes ( 30659077 21829393 25751624 19430480 30572963 18978792) Ulcerative colitis ( 26192919) Vitiligo ( 27723757)	Hip circumference adjusted for BMI ( 28552196) Intelligence ( 22449649) Late-onset Alzheimer's disease ( 27770636)
Interacting Genes		17 interacting genes: AP1M1 AP2M1 CD80 CD86 CTXN3 FYN JAK2 LCK LYN MALL PIK3R1 PPP2R5A PTPN11 STAT5A STAT5B TMEM218 TXK	6 interacting genes: ABCA1 CRKL ERRFI1 GK RBL1 RCHY1
Entrez ID		1493	316
HPRD ID		00474	07537
Ensembl ID		ENSG00000163599	ENSG00000138356
Uniprot IDs		P16410	Q06278
PDB IDs		1AH1 1H6E 1I85 1I8L 2X44 3BX7 3OSK 5GGV 5TRU 5XJ3 6RP8 6RPJ 6RQM	4UHW 4UHX 5EPG 6Q6Q
Enriched GO Terms of Interacting Partners?
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