CSTF2 and CNOT2

Data Source:
BioGRID (two hybrid)

		CSTF2	CNOT2
Description		cleavage stimulation factor subunit 2	CCR4-NOT transcription complex subunit 2
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GO Annotations	Cellular Component	Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex Nuclear Body Cleavage Body	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane CCR4-NOT Complex CCR4-NOT Core Complex
	Molecular Function	RNA Binding MRNA Binding Protein Binding	RNA Polymerase II Transcription Corepressor Binding Transcription Coregulator Activity Poly(A)-specific Ribonuclease Activity Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome Termination Of RNA Polymerase II Transcription MRNA Polyadenylation TRNA Splicing, Via Endonucleolytic Cleavage And Ligation MRNA 3'-end Processing Pre-mRNA Cleavage Required For Polyadenylation	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation Regulation Of Transcription By RNA Polymerase II Regulation Of Translation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Gene Silencing By RNA Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Regulation Of Stem Cell Population Maintenance
Pathways		tRNA processing in the nucleus mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs	Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis (age of onset) ( 22959728) Diastolic blood pressure ( 27841878) Ovarian cancer ( 30557369) Triglyceride levels ( 32154731)
Interacting Genes		49 interacting genes: ABHD11 AKAP8L ANKRD10 APP ATP23 BAG6 CDSN CEACAM6 CEP126 CHD3 CNOT2 CSTF3 CTBP2 DDX1 ECH1 EEF1G ELP1 ERG28 FAM168B FEZ1 HDHD3 HGS IMMT INCA1 KAT5 METTL15 METTL27 MIR19A MIR92A2 POLR2A POU6F2 PPP1R32 PRDM6 RFX6 SPAG8 SS18L1 STH SUB1 SYMPK TFG TLE3 TLE5 TSC1 UBQLN1 UBQLN2 UBQLN4 UFSP1 USP54 ZNF341	26 interacting genes: ARMC5 BCL6 BEX1 C11orf1 C20orf85 CCHCR1 CNOT1 CNOT3 CNOT4 CNOT8 CSTF2 DDB1 GALNT10 GCSAM GPS1 GPS2 HSF2BP MTFR1L NCOR1 NCOR2 PRR35 PSMB4 RACK1 TBX2 TEKT3 ZFHX3
Entrez ID		1478	4848
HPRD ID		02652	05367
Ensembl ID		ENSG00000101811	ENSG00000111596
Uniprot IDs		B3V096 B4DUD5 E7EWR4 P33240	A0A024RBD8 B2RDX7 B3KTL6 F8VUB4 F8VV52 Q9NZN8
PDB IDs		1P1T 2J8P 6Q2I 6TZE	4C0D 4C0F 5FU6 5FU7
Enriched GO Terms of Interacting Partners?
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