NCAN and ZNF121

Data Source:
BioGRID (proximity labelling technology)

		NCAN	ZNF121
Description		neurocan	zinc finger protein 121
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Golgi Lumen Extracellular Matrix Lysosomal Lumen	Nucleus
	Molecular Function	Calcium Ion Binding Hyaluronic Acid Binding Carbohydrate Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding
	Biological Process	Skeletal System Development Cell Adhesion Central Nervous System Development Extracellular Matrix Organization Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process	Regulation Of Transcription By RNA Polymerase II
Pathways		A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS L1CAM interactions NCAM1 interactions Defective B3GALT6 causes EDSP2 and SEMDJL1
Drugs		Beta-D-Glucose Thiodigalactoside Hyaluronic acid
Diseases
GWAS		Bipolar disorder ( 24618891 31043756 21353194) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 19060911 26780889) LDL cholesterol ( 18193043 19060906 19060911 26780889) Nonalcoholic fatty liver disease ( 29385134) Plateletcrit ( 32888494) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656 23974872) Triglycerides ( 18193043 19060906 19060911)
Interacting Genes		8 interacting genes: CNTN2 HMGB1 L1CAM NCAM1 PTN PTPRF TNC TNR	8 interacting genes: BARD1 CARD9 KEAP1 KRTAP10-8 RBAK TRIM41 ZNF835 ZNF837
Entrez ID		1463	7675
HPRD ID		02897	15952
Ensembl ID		ENSG00000130287	ENSG00000197961
Uniprot IDs		A0A024R7M3 O14594 Q4LE67	P58317
PDB IDs
Enriched GO Terms of Interacting Partners?
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